Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. NDC1 Antibody

NDC1 Antibody

  • 货号：
    CSB-PA874808LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA874808LA01HU diluted at 1:300 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NDC1 Polyclonal antibody
  • Uniprot No.：
    Q9BTX1
  • 基因名：
    NDC1
  • 别名：
    NDC1; TMEM48; Nucleoporin NDC1; hNDC1; Transmembrane protein 48
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nucleoporin NDC1 protein (385-517AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NDC1 Antibody (CSB-PA874808LA01HU)，的标记方式是Non-conjugated。对于NDC1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA874808LB01HU NDC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA874808LC01HU NDC1 Antibody, FITC conjugated
    Biotin CSB-PA874808LD01HU NDC1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
  • 基因功能参考文献：
    1. miR-421 can suppress TMEM48 so that leads the non-small cancer cell lines (A549) to apoptosis. PMID: 29906465
    2. In mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail. PMID: 27854341
    3. The biological relevance of TMEM48 in NSCLC progression. PMID: 26392108
    4. Human homologue NDC1/NET3 contains three FG repeats in the C-terminus, a feature of many nuclear pore proteins. PMID: 16779818
    5. NDC1-mediated localization of ALADIN to nuclear pore complexes is essential for selective nuclear protein import; abrogation of the interaction between ALADIN and NDC1 may be important for the development of triple-A syndrome. PMID: 19703420
    6. ALADIN is anchored in the nuclear envelope via NDC1 and that this interaction gets lost, if ALADIN is mutated. PMID: 19782045

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
  • 蛋白家族：
    NDC1 family
  • 数据库链接：

    HGNC: 25525

    OMIM: 610115

    KEGG: hsa:55706

    STRING: 9606.ENSP00000360483

    UniGene: Hs.476525