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  4. Recombinant Human Nucleoporin NDC1 (TMEM48), partial

Recombinant Human Nucleoporin NDC1 (TMEM48), partial

  • 中文名称：
    人NDC1重组蛋白
  • 货号：
    CSB-YP874808HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NDC1重组蛋白
  • 货号：
    CSB-EP874808HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NDC1重组蛋白
  • 货号：
    CSB-EP874808HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NDC1重组蛋白
  • 货号：
    CSB-BP874808HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NDC1重组蛋白
  • 货号：
    CSB-MP874808HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NDC1
  • Uniprot No.：
  • 别名：
    NDC1; TMEM48; Nucleoporin NDC1; hNDC1; Transmembrane protein 48
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane.
  • 基因功能参考文献：
    1. miR-421 can suppress TMEM48 so that leads the non-small cancer cell lines (A549) to apoptosis. PMID: 29906465
    2. In mature human spermatozoa, SEPT12 and NDC1 are majorly colocalized in the centrosome regions; however, NDC1 is only slightly co-expressed with SEPT12 at the annulus of the sperm tail. PMID: 27854341
    3. The biological relevance of TMEM48 in NSCLC progression. PMID: 26392108
    4. Human homologue NDC1/NET3 contains three FG repeats in the C-terminus, a feature of many nuclear pore proteins. PMID: 16779818
    5. NDC1-mediated localization of ALADIN to nuclear pore complexes is essential for selective nuclear protein import; abrogation of the interaction between ALADIN and NDC1 may be important for the development of triple-A syndrome. PMID: 19703420
    6. ALADIN is anchored in the nuclear envelope via NDC1 and that this interaction gets lost, if ALADIN is mutated. PMID: 19782045

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  • 亚细胞定位：
    Nucleus, nuclear pore complex. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
  • 蛋白家族：
    NDC1 family
  • 数据库链接：

    HGNC: 25525

    OMIM: 610115

    KEGG: hsa:55706

    STRING: 9606.ENSP00000360483

    UniGene: Hs.476525