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NECAB2 Antibody

  • 中文名称：
    NECAB2兔多克隆抗体
  • 货号：
    CSB-PA015675GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z6G3
  • 基因名：
    NECAB2
  • 别名：
    EF hand calcium binding protein 2 antibody; EF-hand calcium-binding protein 2 antibody; N-terminal EF-hand calcium-binding protein 2 antibody; NECA2_HUMAN antibody; Necab2 antibody; Neuronal calcium binding protein 2 antibody; Neuronal calcium-binding protein 2 antibody; Stip 2 antibody; Stip-2 antibody; Stip2 antibody; Synaptotagmin interacting protein 2 antibody; Synaptotagmin-interacting protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NECAB2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.
  • 基因功能参考文献：
    1. Study suggests that the phenotypic segregation of Neuronal calcium-binding protein 1 and -2 (NECAB1 and -2) to respective excitatory and inhibitory spinal systems can underpin functional modalities in determining the fidelity of synaptic neurotransmission and neuronal responsiveness, and might bear translational relevance to humans. PMID: 26843217
    2. NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function PMID: 19694902
    3. Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18519826
  • 亚细胞定位：
    Cytoplasm. Cell projection, dendrite. Cell projection, axon. Cell membrane.
  • 组织特异性：
    Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level).
  • 数据库链接：

    HGNC: 23746

    KEGG: hsa:54550

    UniGene: Hs.140950