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NEK3 Antibody

  • 中文名称：
    NEK3兔多克隆抗体
  • 货号：
    CSB-PA015701ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: NEK3 antibody at 6.04µg/ml
      Lane 1: MCF-7 whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58, 56 kDa
      Observed band size: 58 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA015701ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015701ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NEK3 Polyclonal antibody
  • Uniprot No.：
    P51956
  • 基因名：
    NEK3
  • 别名：
    NEK3 antibody; Serine/threonine-protein kinase Nek3 antibody; EC 2.7.11.1 antibody; HSPK 36 antibody; Never in mitosis A-related kinase 3 antibody; NimA-related protein kinase 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase Nek3 protein (267-506AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2.
  • 基因功能参考文献：
    1. NEK3 kinase phosphorylates SNAP29 on its serine 105. NEK3-mediated phosphorylation determines membrane localization of SNAP29. Membrane-associated SNAP29 regulates Golgi and focal adhesion structures. PMID: 29454964
    2. The data demonstrate that NEK3 is overexpressed in gastric cancer, which promotes the malignancy of gastric cancer PMID: 29504992
    3. these data support a modulatory role for phosphorylation at NEK3 Thr-165 in focal adhesion maturation and/or turnover to promote breast cancer cell migration. PMID: 27489110
    4. EHD2 interacts with Nek3 [NIMA (never in mitosis in Aspergillus nidulans)-related kinase 3], a serine/threonine kinase. PMID: 21756249
    5. Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3). PMID: 12063396
    6. Nek3 insertion/deletion polymorphism with alterations at 13q14 is associated with cancers PMID: 17118778
    7. Nek3 contributes to prolactin-mediated breast cancer motility through mechanisms involving Rac1 activation and paxillin phosphorylation. PMID: 17297458

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  • 亚细胞定位：
    Cytoplasm. Cell projection, axon.
  • 蛋白家族：
    Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
  • 组织特异性：
    Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain.
  • 数据库链接：

    HGNC: 7746

    OMIM: 604044

    KEGG: hsa:4752

    STRING: 9606.ENSP00000383210

    UniGene: Hs.409989