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NID2 Antibody

  • 中文名称：
    NID2兔多克隆抗体
  • 货号：
    CSB-PA015803GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14112
  • 基因名：
    NID2
  • 别名：
    NID 2 antibody; NID-2 antibody; Nid2 antibody; NID2_HUMAN antibody; Nidogen-2 antibody; Nidogen2 antibody; Osteonidogen antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NID2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
  • 基因功能参考文献：
    1. High NID2 methylation is associated with non-small cell lung cancer. PMID: 29970687
    2. the serum NID2 levels show significant elevation in the ESCC patients and those with relatively high serum NID2 levels ( 32.6 mu mu g/L) are significantly associated with poor survival outcome compared with those with very low serum NID2 levels (< < 20.0 mu mu g/L). PMID: 29278876
    3. Addition of a TWIST1/NID2-based DNA methylation assay adds diagnostic value to urine cytology and the model is sensitive to the classification of equivocal cytology. PMID: 28106542
    4. Promoter methylation of NID2 was significantly higher in nasopharyngeal carcinoma and esophageal squamous cell carcinoma cells. NID2 suppresses the EGFR/Akt and integrin/FAK/PLCgamma metastasis-related pathways. PMID: 27793011
    5. Knockdown of nidogen-2 reduced SOX9 expression, whereas it up-regulated RUNX2 expression PMID: 26683663
    6. The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. PMID: 23681936
    7. combined methylation analysis of Twist homolog 1 and nidogen-2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine. PMID: 23682613
    8. Decreased nidogen-2 expression is associated with hepatocellular carcinoma PMID: 21815147
    9. NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma. PMID: 21558411
    10. Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125. PMID: 19883638
    11. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2 PMID: 11733994
    12. found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development PMID: 12005023
    13. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
    14. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
    15. CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines. PMID: 17328794

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 组织特异性：
    Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
  • 数据库链接：

    HGNC: 13389

    OMIM: 605399

    KEGG: hsa:22795

    STRING: 9606.ENSP00000216286

    UniGene: Hs.369840