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NIT2 Antibody

  • 中文名称：
    NIT2兔多克隆抗体
  • 货号：
    CSB-PA015823GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NQR4
  • 基因名：
    NIT2
  • 别名：
    CUA002 antibody; MGC111199 antibody; NIT 2 antibody; Nit protein 2 antibody; NIT2 antibody; NIT2_HUMAN antibody; Nitrilase family member 2 antibody; Nitrilase homolog 2 antibody; Omega amidase NIT2 antibody; Omega-amidase NIT2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NIT2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively.
  • 基因功能参考文献：
    1. Downregulation of NIT2 inhibits colon cancer cell proliferation and induces cell cycle arrest through the caspase-3 and PARP pathways PMID: 25738796
    2. Human NIT1/2 are not involved in the metabolism of vildagliptin. PMID: 25008847
    3. The activity and substrate specificity of human Nit2 was determined with alpha-ketoglutaramate and succinamate as substrates. PMID: 22674578
    4. Genotype analysis in 4 types of tumor tissue showed allelic imbalance surrounding NIT2 locus; results show that NIT2 plays an important role in cell growth inhibition & links to malignancies, suggesting Nit2 may be a potential tumor suppressor candidate PMID: 17488281
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Carbon-nitrogen hydrolase superfamily, NIT1/NIT2 family
  • 组织特异性：
    Detected in fetal brain (at protein level). Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, prostate, spleen, thymus, prostate, testis, ovary, small intestine and colon.
  • 数据库链接：

    HGNC: 29878

    KEGG: hsa:56954

    STRING: 9606.ENSP00000377696

    UniGene: Hs.439152