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NOLC1 Antibody

  • 货号：
    CSB-PA048370
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from K562 cells, using NOLC1 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NOLC1 Polyclonal antibody
  • Uniprot No.：
    Q14978
  • 基因名：
    NOLC1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human NOLC1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities.
  • 基因功能参考文献：
    1. In this study, the disordered feature of Nopp140 and the effect of CK2alpha on the structure of Nopp140 were examined using single-molecule fluorescence resonance energy transfer (smFRET) and electron paramagnetic resonance (EPR). PMID: 27297113
    2. D120 and R195 of H5N1 influenza virus NS1 were crucial for the binding to host NOLC1. PMID: 25645906
    3. pRb2/p130 cytoplasmic delocalization can lead to cell cycle deregulation PMID: 25205458
    4. our study demonstrated that DNA methylation is a key mechanism of silenced NOLC1 expression in human hepatocellular carcinoma cells, and NOLC1 gene hypermethylation of the four CpG dinucleotides is a potential biomarker for hepatocellular carcinoma. PMID: 23970161
    5. A Nopp140 fragment (residues 568-596) and inositol hexakisphosphate competitively bind to the catalytic subunit of CK2 (CK2alpha), and phospho-Ser574 of Nopp140 significantly enhances its interaction with CK2alpha. PMID: 24218616
    6. H5N1 viral NS1 interacts with host NOLC1 protein. PMID: 23188192
    7. Structural disorder and local order of hNopp140 PMID: 22906532
    8. The regulation of NOCL1 protein is a critical role for the transcription NF-kB and cAMP response element-bing protein PMID: 21266110
    9. NOPP140 is involved in a PKA signaling pathway that leads to agp activation PMID: 12167624
    10. These data show that Nopp140 reversibly associates with snoRNPs in a phosphorylation-dependent manner, but this association has no effect on pseudouridylation of rRNA. PMID: 12446766
    11. Hypoxia induces substantial p130 dephosphorylation and nuclear accumulation, leading to the formation of E2F4/p130 complexes and increased occupancy of E2F4 and p130 at the RAD51 and BRCA1 promoters. PMID: 17001309
    12. hNopp140 serves as a negative regulator of CK2 and InsP(6) stimulates the activity of CK2 by blocking the interaction between hNopp140 and CK2 PMID: 17038328
    13. Evolutionarily conserved multisubunit protein complex that contains p130 and E2F4 mediates the repression of cell cycle-dependent genes in quiescence. PMID: 17531812
    14. hNopp140, a scaffold protein, is involved in the nucleolar assembly, fusion, and maintenance PMID: 18253863
    15. InsP(6) specifically binds to CK2alpha and disrupts the interaction between CK2alpha and Nopp140 with an IC(50) value of 25 microM, thereby attenuating the Nopp140-mediated repression of CK2 activity. PMID: 18790693
    16. The functional deficiency in spinal muscular atrophy cells is associated with decreased localization of the snoRNP chaperone Nopp140 in Cajal bodies that correlates with disease severity. PMID: 19129172
    17. Nopp140 could be a component implicated in the early steps of pre-rRNA processing. PMID: 19381672
    18. both NOLC1 and tumor protein 53 work together synergistically to activate the MDM2 promoter in NPC cells. PMID: 19541936

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  • 亚细胞定位：
    Nucleus, nucleolus. Cytoplasm.
  • 数据库链接：

    HGNC: 15608

    OMIM: 602394

    KEGG: hsa:9221

    STRING: 9606.ENSP00000359024

    UniGene: Hs.523238