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NOTUM Antibody

  • 货号：
    CSB-PA747435LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue, Mouse stomach tissue
      All lanes: NOTUM antibody at 2.7μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 56 kDa
      Observed band size: 56 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) NOTUM Polyclonal antibody
  • Uniprot No.：
    Q6P988
  • 基因名：
  • 别名：
    NOTUM antibody; notum pectinacetylesterase homolog (Drosophila) antibody; Notum pectinacetylesterase homolog antibody; NOTUM_HUMAN antibody; Protein notum homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Palmitoleoyl-protein carboxylesterase NOTUM protein (100-235AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，NOTUM Antibody (CSB-PA747435LA01HU)，的标记方式是Non-conjugated。对于NOTUM Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA747435LB01HU NOTUM Antibody, HRP conjugated ELISA
    FITC CSB-PA747435LC01HU NOTUM Antibody, FITC conjugated
    Biotin CSB-PA747435LD01HU NOTUM Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors.
  • 基因功能参考文献：
    1. NOTUM expression was increased in metastatic cells. Proliferation was suppressed by inhibiting expression of NOTUM. Knockdown of NOTUM genes inhibited proliferation as well as migration, with possible involvement of p38 and c-JUN N-terminal kinase in this process. PMID: 30343282
    2. Data show that notum and glypican-1 and glypican-3 gene expression during colorectal cancer (CRC) development and present evidence to suggest them as potential new biomarkers of CRC pathogenesis. PMID: 26517809
    3. Kinetic and mass spectrometric analyses of human proteins show that Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins and thus constitutes the first known extracellular protein deacylase PMID: 25731175
    4. Overexpression of NOTUM is associated with hepatocellular carcinoma PMID: 18429952
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Pectinacetylesterase family, Notum subfamily
  • 组织特异性：
    Rarely expressed in adult normal tissues.
  • 数据库链接：

    HGNC: 27106

    OMIM: 609847

    KEGG: hsa:147111

    STRING: 9606.ENSP00000387310

    UniGene: Hs.106137