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  4. NSF Antibody

NSF Antibody

  • 货号：
    CSB-PA020159
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of CoLo cells using NSF Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P46459
  • 基因名：
  • 别名：
    N ethylmaleimide sensitive factor antibody; N ethylmaleimide sensitive factor like protein antibody; N ethylmaleimide sensitive fusion protein antibody; N-ethylmaleimide-sensitive fusion protein antibody; NEM sensitive fusion protein antibody; NEM-sensitive fusion protein antibody; NSF antibody; NSF_HUMAN antibody; SKD 2 antibody; SKD2 antibody; Vesicle fusing ATPase antibody; Vesicle-fusing ATPase antibody; Vesicular fusion protein NSF antibody; Vesicular-fusion protein NSF antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NSF.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling.
  • 基因功能参考文献：
    1. A large copy number variant (CNV) that encompasses part of the NSF gene contributes to cocaine dependence. PMID: 27498889
    2. NSF deficiency in HeLa cells barely affected cell viability, anterograde trafficking of vesicular stomatitis virus glycoprotein G and transferrin endocytosis. PMID: 27995606
    3. a processive helicase-like mechanism for NSF in which approximately 1 residue is unwound for every hydrolyzed ATP molecule. PMID: 23775070
    4. Single and multiple-marker analyses revealed a strong association between cocaine dependence and the NSF gene. PMID: 21426264
    5. Knockdown of TRX1 increases the level of S-nitrosylated NSF, prolongs the inhibition of exocytosis, and suppresses leukocyte PMID: 21324905
    6. NSF independent fusion of Salmonella-containing late phagosomes with early endosomes. PMID: 20176016
    7. analysis of human NSF possible binding mode to GABARAP and GATE-16 PMID: 19533740
    8. binding of NSF to GluR2-containing AMPARs in stabilizing these receptors in the synaptic membrane and impeding their regulated endocytosis. PMID: 12011465
    9. role of interaction with GluR2 in regulation of AMPA receptors by brain-derived neurotrophic factor PMID: 12130635
    10. Nitric oxide regulates exocytosis by S-nitrosylation of NSF. PMID: 14567912
    11. Expressing a biochemically defined NSF mutant that lacks ATPase activity results in a dramatic inhibition of stimulated mast cell exocytosis. PMID: 14607937
    12. NSF dissociates the VAMP-2.SNAP-25.syntaxin 13 complex, but has no effect on the Hrs-containing complex. PMID: 14769786
    13. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein PMID: 16461345
    14. dual regulation on hbeta2AR trafficking and signaling by NSF through direct binding to cargo receptor and its ATPase activity. PMID: 17510209
    15. Data show that NSF is an inclusion body component in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture. PMID: 18836734
    16. Data show that phosphorylation of N-ethylmaleimide-sensitive factor on tyrosine residues prevents its SNARE complex dissociation activity and establish a role for PTP1B in the modulation of the membrane fusion machinery. PMID: 19208619

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    AAA ATPase family
  • 数据库链接：

    HGNC: 8016

    OMIM: 601633

    KEGG: hsa:4905

    STRING: 9606.ENSP00000381293

    UniGene: Hs.431279