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NSG1 Antibody

  • 中文名称：
    NSG1兔多克隆抗体
  • 货号：
    CSB-PA003392
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using NEEP21 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P42857
  • 基因名：
    NSG1
  • 别名：
    Brain neuron cytoplasmic protein 1 antibody; Brain specific mRNA b antibody; Bsmrb antibody; Neuron-specific gene family member 1 antibody; Neuron-specific protein family member 1 antibody; NSG1 antibody; NSG1_HUMAN antibody; PEP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NEEP21.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
  • 基因功能参考文献：
    1. This review focuses on two closely related, neuron-enriched endosomal proteins: NEEP21 and Calcyon which perform distinct roles in regulating receptor endocytosis, recycling, and degradation--{REVIEW} PMID: 25376768
    2. These results suggest that NEEP21 may play a critical role in apoptosis as a mediator of p53. PMID: 20878061
    3. NEEP21 profoundly affects the processing of beta-amyloid precursor proteins and Abeta peptide production. PMID: 21084623
    4. a novel p53-responsive gene D4S234E is accumulated in the ER and induces apoptosis in response to DNA damage. PMID: 20599942
  • 亚细胞定位：
    Membrane; Single-pass type II membrane protein. Golgi apparatus, trans-Golgi network membrane. Endosome membrane. Cell projection, dendrite. Early endosome membrane. Late endosome membrane. Lysosome lumen. Recycling endosome membrane. Cytoplasmic vesicle membrane. Golgi apparatus, Golgi stack membrane. Endosome, multivesicular body membrane. Endoplasmic reticulum membrane.
  • 蛋白家族：
    NSG family
  • 数据库链接：

    HGNC: 18790

    OMIM: 607645

    KEGG: hsa:27065

    STRING: 9606.ENSP00000381049

    UniGene: Hs.518595