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  4. NTNG1 Antibody

NTNG1 Antibody

  • 中文名称：
    NTNG1兔多克隆抗体
  • 货号：
    CSB-PA016131GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y2I2
  • 基因名：
    NTNG1
  • 别名：
    Axon guidance molecule antibody; KIAA0976 antibody; Laminet 1 antibody; LMNT1 antibody; Netrin G1f antibody; Netrin-G1 antibody; Ntng1 antibody; NTNG1_HUMAN antibody; YLSR571 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human NTNG1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
  • 基因功能参考文献：
    1. examined the hypothesis that NTNG1 allelic variation contributes to the risk for schizophrenia PMID: 25325217
    2. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
    3. Our finding nominates the minor G allele of the NTNG1 rs628117 single nucleotide polymorphism as a risk factor for ischemic stroke at least in Armenian population. PMID: 23769687
    4. Genotype and allele frequencies of single nucleotide polymorphisms on NTNG1 are significantly associated with schizophrenia. PMID: 22227940
    5. Netrin-G1 is an important part of the NGL-1 receptor and functions to promote the outgrowth of dorsal thalamic axons. PMID: 14595443
    6. findings suggest that netrin G1 or a nearby gene may contribute to overall genetic risk for schizophrenia PMID: 15508520
    7. Specific haplotypes encompassing alternatively spliced exons of NTNG1 were associated with schizophrenia, and concordantly, messenger ribonucleic acid isoform expression was significantly different between schizophrenic and control brains. PMID: 15705354
    8. Sequence analysis of the cloned junction fragment indicated that on chromosome 1 the predominantly brain-expressed Netrin G1 (NTNG1) gene is disrupted, whereas on chromosome 7 there was no indication for a truncated gene PMID: 15870826
    9. NTNG1 may use alternative splicing to diversify its function in a developmentally and tissue-specific manner. PMID: 15901489
    10. Mutations in the NTNG1 gene appear to be a rare cause of Rett syndrome but NTNG1 function demands further investigation in relation to the central nervous system pathophysiology of the disorder. PMID: 16502428
    11. The data of this stusty implicate NTNG1 in the pathophysiology of schizophrenia and bipolar disorder, but do not support the hypothesis that altered mRNA expression is the mechanism by which genetic variation of NTNG1 may confer disease susceptibility. PMID: 17507910
    12. Netrin G1 is not involved in atypical Rett syndrome or in unexplained encephalopathy with epilepsy, but in specific forms to be delineated better in the future. PMID: 17903671

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
  • 组织特异性：
    Highly expressed in the thalamus, with very low expression, if any, in other tissues.
  • 数据库链接：

    HGNC: 23319

    OMIM: 608818

    KEGG: hsa:22854

    STRING: 9606.ENSP00000359085

    UniGene: Hs.133046