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  4. Recombinant Human Netrin-G1 (NTNG1)

Recombinant Human Netrin-G1 (NTNG1)

  • 中文名称：
    人NTNG1重组蛋白
  • 货号：
    CSB-YP897091HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NTNG1重组蛋白
  • 货号：
    CSB-EP897091HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NTNG1重组蛋白
  • 货号：
    CSB-EP897091HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NTNG1重组蛋白
  • 货号：
    CSB-BP897091HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NTNG1重组蛋白
  • 货号：
    CSB-MP897091HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NTNG1
  • Uniprot No.：
  • 别名：
    Axon guidance molecule; KIAA0976; Laminet 1; LMNT1; Netrin G1f; Netrin-G1; Ntng1; NTNG1_HUMAN; YLSR571
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    29-510
  • 氨基酸序列
    HY DLCKTQIYTE EGKVWDYMAC QPESTDMTKY LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA HPPELMFDFE GRHPSTFWQS ATWKEYPKPL QVNITLSWSK TIELTDNIVI TFESGRPDQM ILEKSLDYGR TWQPYQYYAT DCLDAFHMDP KSVKDLSQHT VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM ASLYGQLDTT KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT ANTCIPSISS IGNCECFGHS NRCSYIDLLN TVICVSCKHN TRGQHCELCR LGYFRNASAQ LDDENVCIEC YCNPLGSIHD RCNGSGFCEC KTGTTGPKCD ECLPGNSWHY GCQPNVCDNE LLHCQNGGTC HNNVRCLCPA AYTGILCEKL RCEEAGSCGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
  • 基因功能参考文献：
    1. examined the hypothesis that NTNG1 allelic variation contributes to the risk for schizophrenia PMID: 25325217
    2. Interaction between the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses. PMID: 23986473
    3. Our finding nominates the minor G allele of the NTNG1 rs628117 single nucleotide polymorphism as a risk factor for ischemic stroke at least in Armenian population. PMID: 23769687
    4. Genotype and allele frequencies of single nucleotide polymorphisms on NTNG1 are significantly associated with schizophrenia. PMID: 22227940
    5. Netrin-G1 is an important part of the NGL-1 receptor and functions to promote the outgrowth of dorsal thalamic axons. PMID: 14595443
    6. findings suggest that netrin G1 or a nearby gene may contribute to overall genetic risk for schizophrenia PMID: 15508520
    7. Specific haplotypes encompassing alternatively spliced exons of NTNG1 were associated with schizophrenia, and concordantly, messenger ribonucleic acid isoform expression was significantly different between schizophrenic and control brains. PMID: 15705354
    8. Sequence analysis of the cloned junction fragment indicated that on chromosome 1 the predominantly brain-expressed Netrin G1 (NTNG1) gene is disrupted, whereas on chromosome 7 there was no indication for a truncated gene PMID: 15870826
    9. NTNG1 may use alternative splicing to diversify its function in a developmentally and tissue-specific manner. PMID: 15901489
    10. Mutations in the NTNG1 gene appear to be a rare cause of Rett syndrome but NTNG1 function demands further investigation in relation to the central nervous system pathophysiology of the disorder. PMID: 16502428
    11. The data of this stusty implicate NTNG1 in the pathophysiology of schizophrenia and bipolar disorder, but do not support the hypothesis that altered mRNA expression is the mechanism by which genetic variation of NTNG1 may confer disease susceptibility. PMID: 17507910
    12. Netrin G1 is not involved in atypical Rett syndrome or in unexplained encephalopathy with epilepsy, but in specific forms to be delineated better in the future. PMID: 17903671

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
  • 组织特异性：
    Highly expressed in the thalamus, with very low expression, if any, in other tissues.
  • 数据库链接：

    HGNC: 23319

    OMIM: 608818

    KEGG: hsa:22854

    STRING: 9606.ENSP00000359085

    UniGene: Hs.133046