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PAK1IP1 Antibody

  • 中文名称：
    PAK1IP1兔多克隆抗体
  • 货号：
    CSB-PA017405GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NWT1
  • 基因名：
    PAK1IP1
  • 别名：
    PAK1IP1 antibody; PIP1 antibody; WDR84 antibody; p21-activated protein kinase-interacting protein 1 antibody; PAK/PLC-interacting protein 1 antibody; hPIP1 antibody; PAK1-interacting protein 1 antibody; WD repeat-containing protein 84 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PAK1IP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
  • 基因功能参考文献：
    1. A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PMID: 23935987
  • 亚细胞定位：
    Nucleus, nucleolus.
  • 组织特异性：
    Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.
  • 数据库链接：

    HGNC: 20882

    OMIM: 607811

    KEGG: hsa:55003

    STRING: 9606.ENSP00000368887

    UniGene: Hs.310231