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PDE10A Antibody

  • 中文名称：
    PDE10A兔多克隆抗体
  • 货号：
    CSB-PA282556
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of A549 cells using PDE10A Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y233
  • 基因名：
    PDE10A
  • 别名：
    5''-cyclic phosphodiesterase 10A antibody; cAMP and cAMP inhibited cGMP 3'5' cyclic phosphodiesterase 10A antibody; cAMP and cAMP-inhibited cGMP 3'' antibody; FLJ11894 antibody; HSPDE 10A antibody; HSPDE10A antibody; PDE 10A antibody; PDE10_HUMAN antibody; Pde10a antibody; Phosphodiesterase 10A antibody; Phosphodiesterase 10A1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human PDE10A.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
  • 基因功能参考文献：
    1. childhood onset of chorea with normal cognition and striatal hyperintensities should prompt further evaluation beyond benign hereditary chorea and heterozygous or homozygous mutations in PDE10A can cause such a phenotype. More number of cases needs to be identified before a definite phenotype genotype correlation can be made in such cases. PMID: 29130591
    2. Results indicate that aging is associated with a considerable physiological reduction of the availability of phosphodiesterase 10A enzyme enzyme in the striatum. PMID: 28254508
    3. Collectively, these findings highlight a novel thermoregulatory role for PDE10A in mouse and human adipocytes and promote PDE10A inhibitors as promising candidates for the treatment of obesity and diabetes. PMID: 27247380
    4. The method proposed for quantification of [(11)C]Lu AE92686 binding in applied studies in NHP is based on 63 min PET data and SRTM with cerebellum as a reference region. The study supports that [(11)C]Lu AE92686 can be used for PET examinations of PDE10A binding also in substantia nigra. PMID: 27817159
    5. Studied what regions of the PDE10A gene are transcribed in human putamen and caudate nucleus brain tissue, two sub-regions of the striatum. Surprisingly, twelve novel transcripts were detected, of which three were predicted to be translated into PDE10A proteins with unique N-termini.studies show that there is much more transcript diversity within the PDE10A gene region than initially believed. PMID: 28042091
    6. The PDE10A gene is currently known to be comprised of 23 exons26 and maps to chromosome 6q26,17, 18 a region previously associated with bipolar disorder. PMID: 26905414
    7. germline PDE10A mutations associated with hyperkinetic movement disorder PMID: 27058446
    8. We have demonstrated that de novo dominant mutations in PDE10A are the cause of a unique movement disorder characterized by benign childhood-onset chorea and typical MRI abnormalities of the striatum. PMID: 27058447
    9. cGMP PDE isozymes, PDE5 and 10, are elevated in colon tumor cells compared with normal colonocytes, and inhibitors and siRNAs can selectively suppress colon tumor cell growth PMID: 26299804
    10. Longitudinal data in a cohort of patients with early Huntington disease found PDE10 to be a useful biomarker of disease progression. PMID: 26802091
    11. Lu AF33241 represents a novel PDE2A/PDE10A inhibitor tool which can penetrate the blood brain barrier. PMID: 25941078
    12. Data provide evidence that PDE10 is involved in colon tumorigenesis and show its overexpression in colon tumor cells compared with colonocytes. PMID: 24704829
    13. PDE10A activity in medium spiny neurons in Huntington's disease might still be high in critical subcellular compartments, despite the overall striatal PDE10A decrease measured using positron-emission tomography. PMID: 24353339
    14. HPRT-deficiency alters cAMP/PKA signaling pathway, which is in part due to the increased of PDE10A expression and activi PMID: 23691025
    15. The present study is the first to demonstrate a central role of PDE10A in progressive pulmonary vascular remodeling. PMID: 21494592
    16. The data of this results supported a model whereby PDE10A trafficking and localization can be regulated in response to local fluctuations in cAMP levels. PMID: 20610737
    17. analysis of functional chimeras of the phosphodiesterase 5 and 10 tandem GAF domains PMID: 18635550
    18. Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity. PMID: 19689430

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  • 相关疾病：
    Dyskinesia, limb and orofacial, infantile-onset (IOLOD); Striatal degeneration, autosomal dominant 2 (ADSD2)
  • 亚细胞定位：
    Cytoplasm. Note=Located mostly to soluble cellular fractions.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family
  • 组织特异性：
    Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
  • 数据库链接：

    HGNC: 8772

    OMIM: 610652

    KEGG: hsa:10846

    STRING: 9606.ENSP00000438284

    UniGene: Hs.348762