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PFKFB4 Antibody

  • 货号：
    CSB-PA613704LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA613704LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PFKFB4 Polyclonal antibody
  • Uniprot No.：
    Q16877
  • 基因名：
  • 别名：
    6-bisphosphatase antibody; 6-P2ase 4 antibody; 6-P2ASE testis-type isozyme antibody; 6-phosphofructo-2-kinase antibody; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 antibody; 6PF 2 K/Fru 2,6 P2ase 4 antibody; 6PF 2 K/Fru 2,6 P2ase testis type isozyme antibody; 6PF-2-K/Fru-2 antibody; 6PF-2-K/Fru-2,6-P2ase antibody; Bifunctional enzyme with kinase and biphosphatase activities antibody; F264_HUMAN antibody; Fructose-2 antibody; Fructose-2,6-bisphosphatase antibody; PFK/FBPase 4 antibody; PFKFB4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 protein (266-368AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PFKFB4 Antibody (CSB-PA613704LA01HU)，的标记方式是Non-conjugated。对于PFKFB4 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA613704LB01HU PFKFB4 Antibody, HRP conjugated ELISA
    FITC CSB-PA613704LC01HU PFKFB4 Antibody, FITC conjugated
    Biotin CSB-PA613704LD01HU PFKFB4 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Synthesis and degradation of fructose 2,6-bisphosphate.
  • 基因功能参考文献：
    1. PFKFB4 enhances the invasiveness of breast cancer cells in vitro and in vivo by inducing HA production and PFKFB4-induced expression of HAS2 depends upon the activation of p38 signaling. PMID: 30415245
    2. findings suggest that the Warburg pathway enzyme PFKFB4 acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours PMID: 29615789
    3. Data show that PFKFB4 is the target gene of PPARgamma which modulates the transcriptional activity of its promoter. PMID: 27769068
    4. Our FD models could facilitate a better mechanistic understanding of FD and help develop effective therapeutics for FD and other fibrosis diseases. PMID: 27614159
    5. High PFKFB4 expression is associated with colon and lung cancer. PMID: 28092678
    6. HIF-1alpha transactivates hypoxia-responsive elements (HRE)-D of the promoter region of PFKFB4 in hypoxia condition. PMID: 27181362
    7. Inhibition of PFKFB4 suppresses glycolysis and proliferation of multiple human cancer cell lines. PMID: 26221874
    8. PFKFB4 suppresses oxidative stress and p62 accumulation, without which autophagy is stimulated likely as a ROS detoxification response. PMID: 25772235
    9. Data indicate that the PFKFB4 expressed in multiple transformed cells and tumors functions to synthesize F2,6BP. PMID: 25115398
    10. we found that the glycolytic enzyme PFKFB4 is essential for prostate cancer cell survival by maintaining the balance between the use of glucose for energy generation and the synthesis of antioxidants. PMID: 22576210
    11. PFKFB4 has an important role in the progression of non-muscle-invasive bladder cancer ( PMID: 21396842
    12. PFKFB4 and HO-2 are expressed in a coordinated manner to maintain glucose homeostasis. PMID: 22892400
    13. Data suggest that molecular mechanism by which dihydrotestosterone induces Pfkfb4 (and thus glycolysis) during spermatogenesis involves stimulation of Sertoli cells to secrete FGF-2 (fibroblast growth factor 2); study uses recombinant human Pfkfb4. PMID: 22811469
    14. an essential role of PFKFB4 in the maintenance of brain cancer stem-like cells PMID: 22056879
    15. Sulforaphane is a potent inducer of apoptosis in hepatocellular carcinoma cells via PFKFB4-inhibition pathways. PMID: 21640852
    16. Mechanisms of hypoxic regulation of PFKFB4 gene expression were studied in several cancer cell lines. PMID: 15474002
    17. A detailed analysis of the 5'-flanking region of human gene pfkfb4 using different 5'-deletion promoter constructs was carried out; this gene is activated by serum and chemical hypoxia whereas beta-estradiol decreases its expression. PMID: 15642344
    18. Overexpression of PFKFB-4 transcript levels in breast & colon malignant tumors correlates with enhanced expression of PFKFB-3, hypoxia-inducible factor(HIF)-1alpha & known HIF-1 dependent genes Glut1 & VEGF PMID: 15925437

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  • 蛋白家族：
    Phosphoglycerate mutase family
  • 数据库链接：

    HGNC: 8875

    OMIM: 605320

    KEGG: hsa:5210

    STRING: 9606.ENSP00000232375

    UniGene: Hs.476217