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PHIP Antibody

  • 中文名称：
    PHIP兔多克隆抗体
  • 货号：
    CSB-PA017921GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WWQ0
  • 基因名：
    PHIP
  • 别名：
    PHIP antibody; DCAF14 antibody; WDR11 antibody; PH-interacting protein antibody; PHIP antibody; DDB1- and CUL4-associated factor 14 antibody; IRS-1 PH domain-binding protein antibody; WD repeat-containing protein 11 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human PHIP
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
  • 基因功能参考文献：
    1. The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. PMID: 30018425
    2. These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration. PMID: 24005052
    3. The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients. PMID: 22511720
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in myeloma and epidermoid carcinoma cell lines.
  • 数据库链接：

    HGNC: 15673

    OMIM: 612870

    KEGG: hsa:55023

    STRING: 9606.ENSP00000275034

    UniGene: Hs.511817