PIK3C3 Antibody

1. Vps34 stimulates tumor development mainly through PKC-delta- activation of p62. PMID: 28846113
2. Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure. PMID: 27385829
3. This study reveals NRBF2 as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation. PMID: 28059666
4. Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1-ATG14 (human), were characterized. PMID: 27630019
5. p300-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed. PMID: 28844862
6. Low VPS34 expression is associated with cancer. PMID: 28157699
7. Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway. PMID: 26686095
8. Vps34 has a previously unknown role in regulating Rab7 activity and late endosomal trafficking. PMID: 27793976
9. High expression of VPS34 promoted GRP78 transcription by modulating ATF6. VPS34 could enhance GRP78 protein stability. PMID: 28038917
10. These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling. PMID: 27821547
11. Study identifies a key role of Cul3-KLHL20 in autophagy termination by controlling autophagy-dependent turnover of ULK1 and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism. PMID: 26687681
12. cis-unsaturated fatty acids require neither BECN1 nor PIK3C3 to stimulate the autophagic flux PMID: 25714112
13. tubulation requires mTOR activity, and we identified two direct mTOR phosphorylation sites on UVRAG (S550 and S571) that activate VPS34. PMID: 26139536
14. High expression of PI3K core complex genes is associated with poor prognosis in chronic lymphocytic leukemia. PMID: 25840748
15. reveal a novel function of GABP in the regulation of autophagy via transcriptional activation of the BECN1-PIK3C3 complex PMID: 25046113
16. Data indicte that Compound 31 constitutes an optimized class III phosphoinositide 3-kinase Vps34 inhibitor that could be used to investigate cancer biology. PMID: 25402320
17. VPS34-IN1 will provide a useful tool to decipher the kinase-dependent functions of Vps34, with acute changes in SGK3 phosphorylation and subcellular localization being new biomarkers of Vps34 activity. PMID: 25395352
18. DNA damage regulates Vps34 complexes and its downstream mechanisms, including autophagy and receptor endocytosis, through SCF (Skp1-Cul1-F-box)-mediated ubiquitination and degradation PMID: 25593308
19. Insulin can spatially regulate VPS34 activity through Src-mediated tyrosine phosphorylation. PMID: 24582588
20. Ric-8A co-localized with Vps34 at the midbody. PMID: 24466196
21. A mechanistic link between amino acid starvation and autophagy induction via the direct activation of the autophagy-specific PIK3C3 kinase. PMID: 24013218
22. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. PMID: 24785657
23. Via direct interaction with the class III PI-3-kinase (PI3KC3)/Beclin1, DEDD activated autophagy and induced the degradation of Snail and Twist, two master regulators of EMT PMID: 22719072
24. Results describe PKD as a novel Vps34 kinase that functions as an effecter of autophagy under oxidative stress. PMID: 22095288
25. conclude that Slamf1 recruits a subset of Vps34-associated proteins, which is involved in membrane fusion and NOX2 regulation PMID: 22493499
26. Though dispensable for autophagy induction, transgenic Vps34 is a critical regulator of naive T cell homeostasis, modulating interleukin (IL)-7 receptor alpha trafficking, signaling, and recycling. PMID: 22021616
27. Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway PMID: 22024166
28. Pik3c3 is essential for central nervous system neuronal homeostasis and Pik3c3 deletion; CaMKII-Cre transgenic mouse is a useful model for studying pathological changes in progressive forebrain neurodegeneration. PMID: 20955765
29. Coimmunoprecipitation assay indicated that hepatitis C virus NS4B formed a complex with human Rab5 and Vps34, supporting the notion that Rab5 and Vps34 are involved in NS4B-induced autophagy. PMID: 21835792
30. Activation of mTOR by leucine or insulin upregulated hVps34. PMID: 21702994
31. 14-3-3zeta proteins are shown as a negative regulator of autophagy through regulation of a key component of early stages of the autophagy pathway, such as hVps34. PMID: 20885446
32. a critical role of the Rubicon RUN domain in PI3KC3 and autophagy regulation PMID: 21062745
33. A specific sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates both receptor degradation and cytokinesis, whereas ATG14L, a PI3K-III subunit involved in autophagy, is not required. PMID: 20643123
34. A PIK3C3 promoter variant (rs3813065/-442 C/T) in an independent multiancestral cohort of 478 systemic lupus erythematosus cases and 522 controls, was examined. PMID: 20671926
35. Data show that knockdown of Vps34 reduces gossypol-induced autophagy in both MCF-7 human breast adenocarcinoma and HeLa cell lines. PMID: 20529838
36. A phylogenetic study revealing co-evolution of myotubularins phosphoinositides phosphatases with PI 3-kinase class III complex PMID: 18774718
37. was expressed in cancer tissues at 11 times the level of that found in normal tissue; findings suggest that activation of the PI3K-AKT signal pathway is associated with oral carcinogenesis PMID: 19887755
38. Results describe how Mycobacterium tuberculosis toxin lipoarabinomannan causes phagosome maturation arrest, interfering with a calcium/calmodulin phosphatidylinositol (PI)3 kinase hVPS34 cascade. PMID: 12925680
39. Data identify rab7 as an important regulator of late endosomal VPS34 function and link rab7 to the regulation of phosphatidylinositol 3'-kinase cycling between early and late endosomes. PMID: 14617358
40. A promoter mutation in a PI regulator affecting the binding of a POU-type transcription factor may be involved in BD and SZ in a subset of patients. PMID: 15121481
41. hVps34 is a nutrient-regulated lipid kinase that integrates amino acid and glucose inputs to mTOR and S6K1 PMID: 16049009
42. Amino acids mediate mTOR activation by signaling through class 3 PI3K, hVps34. PMID: 16176982
43. Results argue against a role for Beclin 1 as an essential chaperone or adaptor for hVps34 in normal vesicular trafficking, and they support the hypothesis that Beclin 1 functions mainly to engage hVps34 in the autophagic pathway. PMID: 16390869
44. There is a connection between Beclin 1-associated Class III PI3K/Vps34-dependent autophagy, but not VPS, function and the mechanism of Beclin 1 tumor suppressor action in human breast cancer cells. PMID: 16874027
45. study indicates that hVps34 and its product PI(3)P are involved in endosome to Golgi transport of ricin, and that SNX2 and SNX4 are likely to be effectors in this pathway PMID: 17319803
46. the lipid kinase activity of Vps34 has a role in resveratrol-induced apoptosis and in the formation of autophagolysosomes PMID: 18048384
47. our results do support PIK3C3 play a significant role in the etiology of schizophrenia PMID: 18420347
48. SopB mediates PI(3)P production on the SCV indirectly through recruitment of Rab5 and its effector Vps34. PMID: 18725540
49. hVps34 activity is regulated through its interactions with hVps15, but is independent of Ca2+/CaM. PMID: 18957027

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HGNC: 8974

OMIM: 602609

KEGG: hsa:5289

STRING: 9606.ENSP00000262039

UniGene: Hs.464971