Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. PJA2 Antibody

PJA2 Antibody

  • 中文名称：
    PJA2兔多克隆抗体
  • 货号：
    CSB-PA003792
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of Jurkat cells using PJA2 Polyclonal Antibody
    • Western Blot analysis of various cells using PJA2 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O43164
  • 基因名：
    PJA2
  • 别名：
    E3 ubiquitin protein ligase Praja2 antibody; E3 ubiquitin-protein ligase Praja-2 antibody; KIAA0438 antibody; Neurodap 1 antibody; Neurodap1 antibody; PJA 2 antibody; PJA2 antibody; PJA2_HUMAN antibody; Praja 2 antibody; Praja 2 RING H2 motif containing antibody; praja ring finger 2 antibody; Praja ring finger 2 E3 ubiquitin protein ligase antibody; Praja2 antibody; RING finger protein 131 antibody; RNF 131 antibody; RNF131 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PJA2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.
  • 基因功能参考文献：
    1. Proper ubiquitin chain assembly by PJA2 requires that Tat first binds its P-TEFb cofactor. PMID: 28345603
    2. The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade. PMID: 23652010
    3. Detection of PJA2-FER fusion mRNA is correlated with poor postoperative survival periods in non-small cell lung cancer. PMID: 23931849
    4. praja2 is a novel cancer-related gene whose expression is linked to the histotype and mutational status of the thyroid tumor. PMID: 22948757
  • 亚细胞定位：
    Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density.
  • 数据库链接：

    HGNC: 17481

    KEGG: hsa:9867

    STRING: 9606.ENSP00000354775

    UniGene: Hs.483036