PLAGL1 Antibody

1. ZAC expression was studied in transgenic mice. PMID: 15286800
2. report here a novel PLAGL1 promoter (P5) derived from the insertion of a primate-specific, MIR3 SINE retrotransposon. P5 is highly utilized in lymphocytes, particularly in T cells, and like P2, directs biallelic transcription PMID: 28957425
3. Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition. PMID: 28985358
4. PLAGL1 methylation/expression may be altered after assisted reproductive technologies. PMID: 27178226
5. These results suggest that OCT attenuates SGC-7901 cell proliferation by enhancing P300-HAT activity through the interaction of ZAC and P300, causing a reduction in pS10-H3 and an increase in acK14-H3. These findings provide insight for future research on OCT and further demonstrate the potential of OCT to be used as a therapeutic agent for gastric cancer PMID: 28260048
6. High PLAGL1 mRNA and protein levels were associated with Clear Cell Renal Cell Carcinoma. PMID: 26851016
7. Results suggest that dysregulation of PLAGL1 expression may be involved in the progression of colorectal cancer (CRC) but the patient survival data do not confirm applicability of the PLAGL1 expression level as a prognostic factor in CRC. PMID: 26134521
8. Fetal growth can be influenced by altered expression of the PLAGL1 gene network in human placenta. PMID: 24993786
9. DNA deletion and promoter hyper-methylation both contribute to the down-regulation of PLAGL1 in gastric adenocarcinoma PMID: 25091631
10. There is positive correlations between the ZAC1 DMR methylation index (MI) and estimated fetal weight (EFW) at 32 weeks of gestation, weight at birth and weight at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03). PMID: 24316753
11. research identified a specific CpG site where determination of the methylation status was associated with both metastasis-free and overall survival in undifferentiated sarcoma. PMID: 24260468
12. ZAC1 and SSTR2 are down-regulated in non-functioning pituitary adenomas but not in somatotropinomas. PMID: 24098585
13. Paternal methylation aberrations at imprinting control regions of DLK1-GTL2, MEST (PEG1), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages. PMID: 23415968
14. The imprinted PLAGL1 domain is flanked by CTCF-binding sites conserved between species in both expressing and non-expressing cells. PMID: 23295672
15. Based on these findings we conclude that the imprinted gene expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 are conserved between human and bovine PMID: 23153226
16. detected a synonymous variation in the protein-coding exon-2 of PLAGL1 in isolated VSD patients. It is possible that the etiology of isolated VSD might not be directly linked with this mutation PMID: 22784302
17. This work indicates that Zac1 functions are regulated, at least in part, via non-covalent interactions with SUMO-1 for the induction of p21, which is important for the modulation of apoptosis. PMID: 22227369
18. Zac1 is able to interact directly with the Sp1-responsive element in the p21(WAF1/Cip1) gene promoter. PMID: 22001409
19. The specific expression of ZAC in the human fetal beta-cells supports it as the gene involved in transient neonatal diabetes mellitus PMID: 21305342
20. Our study suggests the involvement of the imprinted ZAC gene in the pathogenesis of pheochromocytoma. PMID: 21872827
21. PLAGL1 gene is imprinted, with preferential expression from the paternal allele in many tissues. PMID: 10655556
22. Tissue-specific imprinting of PLAGL1 gene results from variable use of monoallelic and biallelic promoters. PMID: 17341487
23. ZAC1 may have a role in tumorigenesis of von Hippel-Lindau associated central nervous system hemangioblastoma. PMID: 20518900
24. ZAC1 is a novel and previously unknown regulator of cardiomyocyte Glut4 expression and glucose uptake; MEF2 is a regulator of ZAC1 expression in response to induction of hypertrophy PMID: 20363751
25. Data indicates that downregulation of ZAC occurs in diffuse large B-cell lymphoma. As ZAC expression in normal B lymphocytes is derived from promoter P2, in DLBCL we analyzed both promoter P1 and P2 for gene expression, LOH and abnormal methylation. PMID: 20175198
26. genetically imprinted in neonatal diabetes PMID: 11935319
27. This candidate tumor suppressor gene, located at chromosome 6q24-25, is epigenetically regulated in cancer PMID: 12473647
28. Zac contains transactivation activities that are differentially controlled by DNA binding. PMID: 12529403
29. The altered expression and LOH of the LOT1 locus support the gene's potential role in the pathogenesis of ovarian cancer and possibly in other types of cancer. PMID: 15581945
30. Mutated in multiple congenital abnormalities including neonatasl diabstes, hypoplastic pasnscreas, intestinal atresia and gallbladdre dysplasia. PMID: 15592663
31. Mutations in ZAC may contribute to Beckwith-Wiedemann syndrome. PMID: 15888726
32. Down-regulation of PLAGL1 is associated with extraskeletal myxoid chondrosarcoma tumors PMID: 16112421
33. Loss of ZAC expression is associated with basal cell carcinomas of skin. PMID: 16179495
34. Using the ZAC1-specific marker located at 6q24-25, LOH or allelic imbalance was observed. PMID: 16733217
35. coordinated binding of Zac zinc fingers and C terminus to p300 regulates HAT function by increasing histone and acetyl coenzyme A affinities and catalytic activity PMID: 16809786
36. a transgene carrying the human HYMAI/PLAGL1 differentially methylated region was methylated in the correct parent-origin-specific manner in mice and this was sufficient to confer imprinted expression from the transgene PMID: 16928428
37. a functional relationship between Zac and PPARgamma that could be relevant to the understanding of tumorigenesis and diabetes as well. PMID: 17178896
38. Absence of unmethylated ZAC1 sequence was highly concurrent with ZAC1 region LOH or 6q loss and with lack of ZAC1 expression, suggesting preferential loss of nonimprinted, expressed ZAC1 allele in capillary hemangioblastoma. PMID: 17805016
39. Zac1 might be involved in regulating the p21(WAF1/Cip1) gene and protein expression through its protein-protein interaction with p53 and HDAC1 in HeLa cells. PMID: 18644983
40. Here it is shown that Zac1, together with the coactivators p300 and PCAF, recruit to the p21(Cip1) promoter during the differentiation of embryonic stem cells into neurons. PMID: 18663001
41. No evidence was found that polymorphisms in ZAC1 might influence anthropometric, biochemical or clinical parameters in French individuals. PMID: 19155788
42. The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte. PMID: 19423711
43. Our results do not indicate a relevant role of mutations in LOT1(ZAC1/PLAGL1) in the etiology of Silver-Russell Syndrome. PMID: 19694203

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HGNC: 9046

OMIM: 603044

KEGG: hsa:5325

STRING: 9606.ENSP00000346810

UniGene: Hs.743225