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  4. Recombinant Human Zinc finger protein PLAGL1 (PLAGL1)

Recombinant Human Zinc finger protein PLAGL1 (PLAGL1)

  • 中文名称：
    人PLAGL1重组蛋白
  • 货号：
    CSB-YP892351HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PLAGL1重组蛋白
  • 货号：
    CSB-EP892351HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PLAGL1重组蛋白
  • 货号：
    CSB-EP892351HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PLAGL1重组蛋白
  • 货号：
    CSB-BP892351HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PLAGL1重组蛋白
  • 货号：
    CSB-MP892351HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PLAGL1
  • Uniprot No.：
  • 别名：
    DKFZp781P1017; Lost on transformation 1; Lost on Transformation; LOT-1; LOT1; MGC126275; MGC126276; PLAG like 1; PLAGL1; PLAL1_HUMAN; Pleiomorphic adenoma gene like 1; Pleiomorphic adenoma gene like protein 1; Pleiomorphic adenoma-like protein 1; Tumor supressor ZAC; ZAC; ZAC tumor supressor; ZAC1; Zinc finger protein PLAGL1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-463
  • 氨基酸序列
    MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM RHMATHSPQK SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY NTMLGYKRHL ALHAASSGDL TCGVCALELG STEVLLDHLK AHAEEKPPSG TKEKKHQCDH CERCFYTRKD VRRHLVVHTG CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP PFPLGASAQN GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD LAKGNAGKVN LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN STLALGPGES LPHRLSCLGQ QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT GSAILPHFHH AFR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide.
  • 基因功能参考文献：
    1. ZAC expression was studied in transgenic mice. PMID: 15286800
    2. report here a novel PLAGL1 promoter (P5) derived from the insertion of a primate-specific, MIR3 SINE retrotransposon. P5 is highly utilized in lymphocytes, particularly in T cells, and like P2, directs biallelic transcription PMID: 28957425
    3. Plagl1 is a transcription factor that coordinated the regulation of a subset of imprinted gene network genes and controlled extracellular matrix composition. PMID: 28985358
    4. PLAGL1 methylation/expression may be altered after assisted reproductive technologies. PMID: 27178226
    5. These results suggest that OCT attenuates SGC-7901 cell proliferation by enhancing P300-HAT activity through the interaction of ZAC and P300, causing a reduction in pS10-H3 and an increase in acK14-H3. These findings provide insight for future research on OCT and further demonstrate the potential of OCT to be used as a therapeutic agent for gastric cancer PMID: 28260048
    6. High PLAGL1 mRNA and protein levels were associated with Clear Cell Renal Cell Carcinoma. PMID: 26851016
    7. Results suggest that dysregulation of PLAGL1 expression may be involved in the progression of colorectal cancer (CRC) but the patient survival data do not confirm applicability of the PLAGL1 expression level as a prognostic factor in CRC. PMID: 26134521
    8. Fetal growth can be influenced by altered expression of the PLAGL1 gene network in human placenta. PMID: 24993786
    9. DNA deletion and promoter hyper-methylation both contribute to the down-regulation of PLAGL1 in gastric adenocarcinoma PMID: 25091631
    10. There is positive correlations between the ZAC1 DMR methylation index (MI) and estimated fetal weight (EFW) at 32 weeks of gestation, weight at birth and weight at one year of age (respectively, r = 0.15, 0.09, 0.14; P values = 0.01, 0.15, 0.03). PMID: 24316753
    11. research identified a specific CpG site where determination of the methylation status was associated with both metastasis-free and overall survival in undifferentiated sarcoma. PMID: 24260468
    12. ZAC1 and SSTR2 are down-regulated in non-functioning pituitary adenomas but not in somatotropinomas. PMID: 24098585
    13. Paternal methylation aberrations at imprinting control regions of DLK1-GTL2, MEST (PEG1), and ZAC (PLAGL1) and global methylation levels are not associated with idiopathic recurrent spontaneous miscarriages. PMID: 23415968
    14. The imprinted PLAGL1 domain is flanked by CTCF-binding sites conserved between species in both expressing and non-expressing cells. PMID: 23295672
    15. Based on these findings we conclude that the imprinted gene expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 are conserved between human and bovine PMID: 23153226
    16. detected a synonymous variation in the protein-coding exon-2 of PLAGL1 in isolated VSD patients. It is possible that the etiology of isolated VSD might not be directly linked with this mutation PMID: 22784302
    17. This work indicates that Zac1 functions are regulated, at least in part, via non-covalent interactions with SUMO-1 for the induction of p21, which is important for the modulation of apoptosis. PMID: 22227369
    18. Zac1 is able to interact directly with the Sp1-responsive element in the p21(WAF1/Cip1) gene promoter. PMID: 22001409
    19. The specific expression of ZAC in the human fetal beta-cells supports it as the gene involved in transient neonatal diabetes mellitus PMID: 21305342
    20. Our study suggests the involvement of the imprinted ZAC gene in the pathogenesis of pheochromocytoma. PMID: 21872827
    21. PLAGL1 gene is imprinted, with preferential expression from the paternal allele in many tissues. PMID: 10655556
    22. Tissue-specific imprinting of PLAGL1 gene results from variable use of monoallelic and biallelic promoters. PMID: 17341487
    23. ZAC1 may have a role in tumorigenesis of von Hippel-Lindau associated central nervous system hemangioblastoma. PMID: 20518900
    24. ZAC1 is a novel and previously unknown regulator of cardiomyocyte Glut4 expression and glucose uptake; MEF2 is a regulator of ZAC1 expression in response to induction of hypertrophy PMID: 20363751
    25. Data indicates that downregulation of ZAC occurs in diffuse large B-cell lymphoma. As ZAC expression in normal B lymphocytes is derived from promoter P2, in DLBCL we analyzed both promoter P1 and P2 for gene expression, LOH and abnormal methylation. PMID: 20175198
    26. genetically imprinted in neonatal diabetes PMID: 11935319
    27. This candidate tumor suppressor gene, located at chromosome 6q24-25, is epigenetically regulated in cancer PMID: 12473647
    28. Zac contains transactivation activities that are differentially controlled by DNA binding. PMID: 12529403
    29. The altered expression and LOH of the LOT1 locus support the gene's potential role in the pathogenesis of ovarian cancer and possibly in other types of cancer. PMID: 15581945
    30. Mutated in multiple congenital abnormalities including neonatasl diabstes, hypoplastic pasnscreas, intestinal atresia and gallbladdre dysplasia. PMID: 15592663
    31. Mutations in ZAC may contribute to Beckwith-Wiedemann syndrome. PMID: 15888726
    32. Down-regulation of PLAGL1 is associated with extraskeletal myxoid chondrosarcoma tumors PMID: 16112421
    33. Loss of ZAC expression is associated with basal cell carcinomas of skin. PMID: 16179495
    34. Using the ZAC1-specific marker located at 6q24-25, LOH or allelic imbalance was observed. PMID: 16733217
    35. coordinated binding of Zac zinc fingers and C terminus to p300 regulates HAT function by increasing histone and acetyl coenzyme A affinities and catalytic activity PMID: 16809786
    36. a transgene carrying the human HYMAI/PLAGL1 differentially methylated region was methylated in the correct parent-origin-specific manner in mice and this was sufficient to confer imprinted expression from the transgene PMID: 16928428
    37. a functional relationship between Zac and PPARgamma that could be relevant to the understanding of tumorigenesis and diabetes as well. PMID: 17178896
    38. Absence of unmethylated ZAC1 sequence was highly concurrent with ZAC1 region LOH or 6q loss and with lack of ZAC1 expression, suggesting preferential loss of nonimprinted, expressed ZAC1 allele in capillary hemangioblastoma. PMID: 17805016
    39. Zac1 might be involved in regulating the p21(WAF1/Cip1) gene and protein expression through its protein-protein interaction with p53 and HDAC1 in HeLa cells. PMID: 18644983
    40. Here it is shown that Zac1, together with the coactivators p300 and PCAF, recruit to the p21(Cip1) promoter during the differentiation of embryonic stem cells into neurons. PMID: 18663001
    41. No evidence was found that polymorphisms in ZAC1 might influence anthropometric, biochemical or clinical parameters in French individuals. PMID: 19155788
    42. The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte. PMID: 19423711
    43. Our results do not indicate a relevant role of mutations in LOT1(ZAC1/PLAGL1) in the etiology of Silver-Russell Syndrome. PMID: 19694203

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 数据库链接：

    HGNC: 9046

    OMIM: 603044

    KEGG: hsa:5325

    STRING: 9606.ENSP00000346810

    UniGene: Hs.743225