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PLD3 Antibody

  • 货号：
    CSB-PA018146LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018146LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA018146LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PLD3 Polyclonal antibody
  • Uniprot No.：
    Q8IV08
  • 基因名：
  • 别名：
    Choline phosphatase 3 antibody; HindIII K4L homolog antibody; HU K4 antibody; Hu-K4 antibody; HUK4 antibody; Phosphatidylcholine hydrolyzing phospholipase D3 antibody; Phosphatidylcholine-hydrolyzing phospholipase D3 antibody; Phospholipase D family; member 3 antibody; Phospholipase D3 antibody; PLD 3 antibody; PLD3 antibody; PLD3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Phospholipase D3 protein (70-176AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PLD3 Antibody (CSB-PA018146LA01HU)，的标记方式是Non-conjugated。对于PLD3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018146LB01HU PLD3 Antibody, HRP conjugated ELISA
    FITC CSB-PA018146LC01HU PLD3 Antibody, FITC conjugated
    Biotin CSB-PA018146LD01HU PLD3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.
  • 基因功能参考文献：
    1. Data show that phospholipase D3 (PLD3) functions in endosomal protein sorting and plays an important role in regulating amyloid precursor protein (APP) processing. PMID: 29368044
    2. PLD3 variant V232M was associated with Alzheimer's disease risk in overall sample sets. PMID: 26189833
    3. main findings of our this provide evidence that support the possible role of PLD3 common variants in influencing AD-related neuroimaging phenotypes. PMID: 26232066
    4. Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort PMID: 26411346
    5. one PLD3 variant (rs11667768) was associated with amyloid burden detected by CSF in normal individuals, suggesting the potential role of PLD3 in Abeta pathology PMID: 26402410
    6. The rare coding variant might not play an important role in AD risk in mainland China. PMID: 24866402
    7. genetic and functional data indicate that carriers of PLD3 coding variants have a twofold increased risk for late-onset Alzheimer's disease and that PLD3 influences APP processing PMID: 24336208
    8. PLD3 localizes to lysosomes PMID: 21752829
    9. PLD3 overexpression may inhibit Akt phosphorylation and further block the transduction of insulin signaling in C2C12 cells. PMID: 20112697
    10. Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies. PMID: 16580565
    11. receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner PMID: 19525236

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  • 相关疾病：
    Genetic variants in PLD3 have been suggested to be associated with an increased risk for Alzheimer disease (PubMed:24336208, PubMed:25832409). Further studies, however, did not support PLD3 involvement in this disease (PubMed:25832408, PubMed:25832411, PubMed:25832413, PubMed:25832410, PubMed:26411346).
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Lysosome lumen. Early endosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Phospholipase D family
  • 组织特异性：
    Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.
  • 数据库链接：

    HGNC: 17158

    OMIM: 615698

    KEGG: hsa:23646

    STRING: 9606.ENSP00000348901

    UniGene: Hs.257008