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  4. Recombinant Human Phospholipase D3 (PLD3), partial

Recombinant Human Phospholipase D3 (PLD3), partial

  • 货号：
    CSB-YP816880HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP816880HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP816880HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP816880HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP816880HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Choline phosphatase 3; HindIII K4L homolog; HU K4; Hu-K4; HUK4; Phosphatidylcholine hydrolyzing phospholipase D3; Phosphatidylcholine-hydrolyzing phospholipase D3; Phospholipase D family; member 3 ; Phospholipase D3; PLD 3; PLD3; PLD3_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.
  • 基因功能参考文献：
    1. Data show that phospholipase D3 (PLD3) functions in endosomal protein sorting and plays an important role in regulating amyloid precursor protein (APP) processing. PMID: 29368044
    2. PLD3 variant V232M was associated with Alzheimer's disease risk in overall sample sets. PMID: 26189833
    3. main findings of our this provide evidence that support the possible role of PLD3 common variants in influencing AD-related neuroimaging phenotypes. PMID: 26232066
    4. Rare Variants in PLD3 Do Not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort PMID: 26411346
    5. one PLD3 variant (rs11667768) was associated with amyloid burden detected by CSF in normal individuals, suggesting the potential role of PLD3 in Abeta pathology PMID: 26402410
    6. The rare coding variant might not play an important role in AD risk in mainland China. PMID: 24866402
    7. genetic and functional data indicate that carriers of PLD3 coding variants have a twofold increased risk for late-onset Alzheimer's disease and that PLD3 influences APP processing PMID: 24336208
    8. PLD3 localizes to lysosomes PMID: 21752829
    9. PLD3 overexpression may inhibit Akt phosphorylation and further block the transduction of insulin signaling in C2C12 cells. PMID: 20112697
    10. Our data do not support the hypothesis that the HindIII(+/-) site of the Y chromosome is a marker of cardiovascular risk in white men, highlighting the need for replication in genetic association studies. PMID: 16580565
    11. receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner PMID: 19525236

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  • 相关疾病：
    Genetic variants in PLD3 have been suggested to be associated with an increased risk for Alzheimer disease (PubMed:24336208, PubMed:25832409). Further studies, however, did not support PLD3 involvement in this disease (PubMed:25832408, PubMed:25832411, PubMed:25832413, PubMed:25832410, PubMed:26411346).
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Lysosome lumen. Early endosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Phospholipase D family
  • 组织特异性：
    Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum.
  • 数据库链接：

    HGNC: 17158

    OMIM: 615698

    KEGG: hsa:23646

    STRING: 9606.ENSP00000348901

    UniGene: Hs.257008