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PLEK Antibody

  • 中文名称：
    PLEK兔多克隆抗体
  • 货号：
    CSB-PA018152GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P08567
  • 基因名：
    PLEK
  • 别名：
    FLJ27168 antibody; OTTHUMP00000159962 antibody; p47 antibody; Platelet 47 kDa protein antibody; Platelet and leukocyte C kinase substrate antibody; Platelet P47 antibody; Platelet p47 protein antibody; Pleckstrin antibody; PLEK antibody; PLEK_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PLEK
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Major protein kinase C substrate of platelets.
  • 基因功能参考文献：
    1. Only one gene, pleckstrin , was significantly overexpressed in periodontitis,cardiovascular disease, rheumatoid arthritis and ulcerative colitis , implicating this gene as an important networking link between these chronic inflammatory diseases PMID: 26686060
    2. crystallization and preliminary X-ray diffraction analysis of the first 2 domains of pleckstrin (NPHDEP); work demonstrates that NPHDEP behaves as a monomer in solution and suggests that all 3 pleckstrin domains contribute to the dimerization interface PMID: 21393855
    3. Here they show that the PH domain from Bcr-Abl binds a number of proteins involved in vital cellular processes in leukemogenesis. PMID: 19944685
    4. Translocation requires its phosphorylation and newly formed ligands PMID: 12054651
    5. A pleckstrin homology domain located in G protein-coupled receptor kinase-2 (GRK2) residue 548 to 660 plays a significant role in mediating interaction between protein kinase C beta 1 and GRK2. PMID: 12456365
    6. The human pleckstrin-1 solution nuclear magnetic resonance structure of the C-terminal pleckstrin homology domain was reported. PMID: 15698571
    7. Proteins beta3 integrin, Vav3, Plekhm1, and Src, implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis. PMID: 19546854
    8. Idirect associations between plek and actin through 17 beta-hydroxysteroid dehydrogenase 4, alpha-actinin, moesin, radixin and factor XIIIA, is proposed. PMID: 19722192

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  • 数据库链接：

    HGNC: 9070

    OMIM: 173570

    KEGG: hsa:5341

    STRING: 9606.ENSP00000234313

    UniGene: Hs.468840