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PLXNA2 Antibody

  • 中文名称：
    PLXNA2兔多克隆抗体
  • 货号：
    CSB-PA563141
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA563141(PLXNA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA563141(PLXNA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    O75051
  • 基因名：
    PLXNA2
  • 别名：
    Plexin-A2 antibody; PlexinA2 antibody; PLXA2 antibody; PLXA2_HUMAN antibody; PLXNA2 antibody; Semaphorin receptor OCT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human PLXNA2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
  • 基因功能参考文献：
    1. although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells. PMID: 25335892
    2. PLXNA2 upregulation contributes to TMPRSS2:ERG-mediated enhancements of PC3c cell migration and invasion. PMID: 23708657
    3. PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot. PMID: 22912587
    4. results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 signaling PMID: 22095611
    5. PLXNA2 polymorphisms show association with ankylosing spondylitis. PMID: 22011406
    6. in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types. PMID: 21925246
    7. An association is identified between variants in the PLXNA2 gene and schizophrenia in two collections of schizophrenia cases and controls. High-density SNP mapping showed that the region of association spans approximately 60 kb of the PLXNA2 gene. PMID: 16402134
    8. results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample PMID: 17346868
    9. PLXNA2 confers a varying genetic risk for schizophrenia among different populations. PMID: 18065206
    10. Analysis of 3 SNPs at the PLXN A2 locus; we failed to replicate previously reported association of this locus and schizophrenia. PMID: 18096369
    11. mutations in GATA6 are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C-plexin A2 signaling PMID: 19666519

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Plexin family
  • 组织特异性：
    Detected in fetal brain.
  • 数据库链接：

    HGNC: 9100

    OMIM: 601054

    KEGG: hsa:5362

    STRING: 9606.ENSP00000356000

    UniGene: Hs.497626