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PPHLN1 Antibody

  • 中文名称：
    PPHLN1兔多克隆抗体
  • 货号：
    CSB-PA071399
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO cells and 293 cells, using PPHLN antibody.
    • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using PPHLN antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPHLN1 Polyclonal antibody
  • Uniprot No.：
    Q8NEY8
  • 基因名：
    PPHLN1
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human PPHLN.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation.
  • 基因功能参考文献：
    1. analysis of FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma PMID: 25608663
    2. this study identified the HUSH (human silencing hub) complex, comprising three poorly characterized proteins, TASOR, MPP8, and periphilin; this complex is absent from Drosophila but is conserved from fish to humans. PMID: 26022416
    3. Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD. PMID: 19730898
    4. periphilin is potentially involved in epithelial differentiation and contributes to epidermal integrity and barrier formation PMID: 12853457
    5. CR (periphilin) retards S-phase progression by modifying expression of Cdc7 and other genes involved in progression of DNA replication PMID: 15474462

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Chromosome.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 19369

    OMIM: 608150

    KEGG: hsa:51535

    STRING: 9606.ENSP00000378935

    UniGene: Hs.444157