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PPP1R14A (Ab-38) Antibody

  • 货号：
    CSB-PA794704
  • 规格：
    ￥2024
  • 图片：
    • Immunofluorescence staining of methanol-fixed Hela cells using CPI17a(Ab-38) Antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PPP1R14A Polyclonal antibody
  • Uniprot No.：
    Q96A00
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around aa.36~40 (R-V-T-V-K) derived from Human CPI17a.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:100-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.
  • 基因功能参考文献：
    1. CPI-17 drives Ras activity and tumorigenesis in melanomas in a two-fold way; inactivation of the tumor suppressor merlin and activation of the growth promoting ERM family. PMID: 27793041
    2. The s call the mutual sequestration mechanism through which pCPI-17 and myosin light-chain phosphatase interact inhibition by unfair competition: myosin light-chain phosphatase protects pCPI-17 from other phosphatases, while pCPI-17 blocks other substrates from the active site of myosin light-chain phosphatase. PMID: 28387646
    3. Study finds that CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) is not expressed in the healthy peripheral nervous system or in nontumour pathologies of the peripheral nervous system. CPI-17 up-regulation, however, is observed in over 90% of schwannomas, but not in neurofibroma and only rarely in malignant peripheral nerve sheath tumour. PMID: 27248983
    4. CPI-17 has a role in restoring skin homoeostasis in cutaneous field of cancerization lesions PMID: 23800065
    5. analysis of the interaction between plakoglobin and CPI-17, which is affected by the phosphorylation status of CPI-17 in human lung microvascular endothelial cells PMID: 23583905
    6. The N-terminal 21-residue tail domain of CPI-17 is necessary for nuclear localization. Phospho-mimetic Asp-substitution of CPI-17 at Ser12 attenuates the nuclear import. PMID: 23541585
    7. The study characterized the CPI-17 promoter and identified binding sites for GATA-6 and nuclear factor kappa B (NF-kappaB). PMID: 23275439
    8. a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1alpha, and CPI-17. PMID: 22275376
    9. RACK1 may play a role in PKC/CPI-17 signaling pathway. PMID: 20875397
    10. cAMP/PKA regulates the endothelial barrier via inhibition of the contractile machinery, mainly by the activation of MLCP via inhibition of CPI-17 and RhoA/Rock. PMID: 20202976
    11. mapped to chromosome 19q13.13-q13.2 PMID: 11931393
    12. CPI-17 binds directly to protein kinase C and casein kinase I. PMID: 15003508
    13. importance of PKC/CPI-17-mediated pathway in histamine-triggered cytoskeletal rearrangements leading to lung microvascular barrier compromise. PMID: 15234908
    14. CPI-17 siRNA decreased the level of merlin phosphorylation and consequently Ras and ERK activity in human tumor cell lines PMID: 16885985
    15. These data indicate that 14,15-epoxyeicosatrienoic acid hyperpolarizes airway smooth muscle cells and relaxes precontracted human bronchi and intracellular effects are related to a PKC-dependent process involving a lower phosphorylation level of CPI-17. PMID: 17237191
    16. Human pregnancy is characterized by increases in PKN1 expression and PPP1R14A phosphorylation in the myometrium. PMID: 17301291
    17. These results are consistent with a key molecular role for CPI-17 in airway hyperresponsiveness, in the absence of bronchial wall remodeling. PMID: 18757304
    18. NF2 is rendered inactive by phosphorylation of Ser 518 and this can be explained at least in part by an increased expression of CPI-17. PMID: 18835652

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    PP1 inhibitor family
  • 组织特异性：
    Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
  • 数据库链接：

    HGNC: 14871

    OMIM: 608153

    KEGG: hsa:94274

    STRING: 9606.ENSP00000301242

    UniGene: Hs.631569