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  4. PRELID1 Antibody

PRELID1 Antibody

  • 中文名称：
    PRELID1兔多克隆抗体
  • 货号：
    CSB-PA018661GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y255
  • 基因名：
    PRELID1
  • 别名：
    25 kDa protein of relevant evolutionary and lymphoid interest antibody; CGI 106 antibody; MGC87972 antibody; mitochondrial antibody; PRELI antibody; PRELI domain containing 1 antibody; PRELI domain containing protein 1 antibody; PRELI domain containing protein 1 mitochondrial antibody; PRELI domain-containing protein 1 antibody; PRELID 1 antibody; PRELID1 antibody; PRLD1_HUMAN antibody; Protein of relevant evolutionary and lymphoid interest antibody; PX 19 antibody; PX19 antibody; Px19 like protein antibody; Px19, chicken, homolog of antibody; Px19-like protein antibody; SBBI12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PRELID1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.
  • 基因功能参考文献：
    1. This study suggests that the regulation of PRELID1 expression, by alternative polyadenylation and other mechanisms, plays a role in mitochondrial ROS signaling and represents a novel prognostic factor and therapeutic target in cancer PMID: 28912168
    2. PRELI plays an important role in the suppression of apoptosis in HepG2 cells in response to oxidative stress. PMID: 26275693
    3. Loss of TRIAP1 or PRELI impairs the accumulation of Cardiolipin, facilitates the release of cytochrome c, and renders cells vulnerable to apoptosis upon intrinsic and extrinsic stimulation. PMID: 23931759
    4. PRELI is a vital LEA B cell protein with failsafe genetics PMID: 22666421
    5. PRELI interacts with OPA1 to maintain mitochondria structures intact, sustain balanced ion(-)/proton(+) gradients, promote oxidative phosphorylation reactions, regulate pro- and antiapoptotic protein traffic and enable cell responses to induced death. PMID: 21364629

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  • 亚细胞定位：
    Mitochondrion. Mitochondrion intermembrane space.
  • 组织特异性：
    Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 30255

    OMIM: 605733

    KEGG: hsa:27166

    STRING: 9606.ENSP00000302114

    UniGene: Hs.744904