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PREX2 Antibody

  • 货号：
    CSB-PA741122LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue
      All lanes: PREX2 antibody at 3.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 183, 172, 113 kDa
      Observed band size: 183, 113 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA741122LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA741122LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) PREX2 Polyclonal antibody
  • Uniprot No.：
    Q70Z35
  • 基因名：
  • 别名：
    4 antibody; 5)-dependent Rac exchanger 2 antibody; 5-trisphosphate-dependent Rac exchanger 2 protein antibody; 6230420N16Rik antibody; DEP domain-containing protein 2 antibody; DEP.2 antibody; DEPDC2 antibody; FLJ12987 antibody; P-Rex2 antibody; Phosphatidylinositol 3 antibody; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 antibody; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein antibody; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 antibody; PREX2 antibody; PREX2_HUMAN antibody; PtdIns(3 antibody; PtdIns(3,4,5)-dependent Rac exchanger 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (1417-1592AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，PREX2 Antibody (CSB-PA741122LA01HU)，的标记方式是Non-conjugated。对于PREX2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA741122LB01HU PREX2 Antibody, HRP conjugated ELISA
    FITC CSB-PA741122LC01HU PREX2 Antibody, FITC conjugated
    Biotin CSB-PA741122LD01HU PREX2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:2000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
  • 基因功能参考文献：
    1. Study demonstrates that miR-637 inhibites melanoma cell proliferation by activation of AKT signaling pathway and induces apoptosis through regulation of Bcl-2/Bax expression via targeting P-REX2a. PMID: 30213289
    2. MiR-338-3p suppresses the TNF-alpha-induced lipogenesis in sebocytes by targeting PREX2a and down-regulating PI3K/AKT signaling. PMID: 28597147
    3. complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators PMID: 27111337
    4. PREX2 was identified as a frequently mutated gene in human melanoma. .. mutation of PREX2 can accelerate human melanoma growth. PMID: 28100393
    5. The rapid tumor onset observed in this replication attempt, compared to the original study, makes the detection of accelerated tumor growth in PREX2 expressing NRAS(G12D) melanocytes extremely difficult. PMID: 28100394
    6. Elevated PREX2 protein expression is associated with pathogenesis of hepatocellular carcinoma. PMID: 28205209
    7. knockdown of PREX2a may effectively inhibit the malignant phenotype of glioma. PMID: 26795161
    8. The results of the present study suggested that PREX2a may act as an oncogene in osteosarcoma via the inhibition of PTEN activity and activation of PI3K signaling. PMID: 26718453
    9. findings identify PREX2 as a mediator of NRAS-mutant melanoma development that acts through the PI3K/PTEN/Akt pathway to regulate gene expression of a cell cycle regulator PMID: 26884185
    10. second messengers activate the Rac1 signal, which sets in motion a cascade whereby PAKs phosphorylate and negatively regulate PREX2 to decrease Rac1 activation. PMID: 26438819
    11. PREX2 mutants are likely selected in cancer to escape PTEN-mediated inhibition of invasion. PMID: 25829446
    12. CXCL9 is involved in the invasion ability of hepatocellular carcinoma cells possibly through up-regulation of its potential effector PREX2. PMID: 25151370
    13. Results demonstrate that miR-338-3p affects gastric cancer progression through PTEN-AKT signaling by targeting P-Rex2a in gastric cancer cells PMID: 24375644
    14. P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis PMID: 24367090
    15. MiR-338-3p affects the PTEN/Akt pathway by down-regulating PREX2a. PMID: 24140344
    16. Analysis of whole-genome sequence data identified PREX2 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2)--a PTEN-interacting protein and negative regulator of PTEN in breast cancer--as a significantly mutated gene with a mutation frequency of approximately 14% in an independent extension cohort of 107 human melanomas PMID: 22622578
    17. suggests that aberrant control of PTEN by P-REX2a may represent a key tumorigenic mechanism, in agreement with recent studies supporting the pathological relevance of several other proposed PTEN regulators PMID: 19861688
    18. P-REX2 may serve as a novel link between Rac activation and the PI-3 kinase pathway. PMID: 15304342
    19. P-Rex2 is a 183 kDa protein that activates the small GTPase Rac and is regulated by phosphatidylinositol (3,4,5)-trisphosphate. PMID: 15304343
    20. the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2 has a role in substrate specificity and recognition PMID: 15897194
    21. identified P-REX2a as a PTEN-interacting protein; P-REX2a inhibited PTEN lipid phosphatase activity & stimulated the PI3K pathway only in the presence of PTEN; P-REX2a is a component of the PI3K pathway that can antagonize PTEN in cancer cells PMID: 19729658

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  • 组织特异性：
    Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.
  • 数据库链接：

    HGNC: 22950

    OMIM: 612139

    KEGG: hsa:80243

    STRING: 9606.ENSP00000288368

    UniGene: Hs.169943