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PREX2

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.

PREX2 Antibodies

PREX2 for Homo sapiens (Human)

PREX2 Proteins

PREX2 Proteins for Mus musculus (Mouse)

PREX2 Proteins for Homo sapiens (Human)