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PUS1 Antibody

  • 中文名称：
    PUS1兔多克隆抗体
  • 货号：
    CSB-PA019086GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y606
  • 基因名：
    PUS1
  • 别名：
    A730013B20Rik antibody; DOBI antibody; MGC112655 antibody; MGC11268 antibody; MLASA antibody; MLASA1 antibody; mPus1p antibody; Pseudouridine synthase 1 antibody; Pseudouridylate synthase 1 antibody; PUS1 antibody; tRNA pseudouridine synthase A, mitochondrial antibody; tRNA pseudouridine(38-40) synthase antibody; tRNA pseudouridylate synthase I antibody; tRNA uridine isomerase I antibody; tRNA-uridine isomerase I antibody; TRUA_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PUS1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 RNA.
  • 基因功能参考文献：
    1. results show that the NTD of ERalpha and AR contains a novel RBM that directly binds SRA, and that STR5 can serve as a novel class of RNA inhibitor of ERalpha and AR signaling by interfering with Pus1p-mediated SRA pseudouridylation PMID: 22998747
    2. Investigation of the sequence and structural requirements for hPus1p activity on human tRNASer. PMID: 22102571
    3. We identified one novel homozygous null mutation in a familial case. It predicts a nonsense mutation at glutamine 154 (Q154X) that would lead to a protein lacking the 266 C-terminal amino acids PMID: 19731322
    4. Missense mutation in pseudouridine synthase 1 causes mitochondrial myopathy and sideroblastic anemia PMID: 15108122
    5. MLASA is associated with absent or greatly reduced tRNA pseudouridylation at specific sites, implicating this pathway in its molecular pathogenesis. PMID: 15772074
    6. A new homozygous stop mutation (E220X)predicts a protein missing 208/427 amino acid residues on the C terminus. The nuclear isoform has an N-terminal extension absent in the mature mitochondrial isoform. PMID: 17056637
    7. Three residues (R116, Y173, R267) that correspond to amino acids known to compose the active site of TruA, a bacterial Psi synthase that is homologous to Pus1p, were mutated in human Pus1p. PMID: 18648068

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  • 相关疾病：
    Myopathy with lactic acidosis and sideroblastic anemia 1 (MLASA1)
  • 亚细胞定位：
    [Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
  • 蛋白家族：
    TRNA pseudouridine synthase TruA family
  • 组织特异性：
    Widely expressed. High levels of expression found in brain and skeletal muscle.
  • 数据库链接：

    HGNC: 15508

    OMIM: 600462

    KEGG: hsa:80324

    STRING: 9606.ENSP00000365837

    UniGene: Hs.592004