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  4. Phospho-NIFK (T234) Antibody

Phospho-NIFK (T234) Antibody

  • 货号：
    CSB-PA070019
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9BYG3
  • 基因名：
    NIFK
  • 别名：
    hNIFK antibody; MK67I_HUMAN antibody; MKI67 FHA Domain Interacting Nucleolar Phosphoprotein antibody; MKI67 FHA domain-interacting nucleolar phosphoprotein antibody; mki67ip antibody; NOPP34 antibody; Nucleolar phosphoprotein Nopp34 antibody; Nucleolar protein interacting with the FHA domain of pKI 67 antibody; Nucleolar protein interacting with the FHA domain of pKI-67 antibody; pKi67 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Human NIFK around the phosphorylation site of T234.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. NIFK is required for lung cancer progression via the RUNX1-dependent CK1alpha repression, which activates TCF4/beta-catenin signaling in metastasis and the Ki-67-dependent regulation in cell proliferation. PMID: 26984280
    2. The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression. PMID: 25826659
    3. Potential encounter complexes of the Ki67FHA receptor and hNIFK peptide are misregistered states of the beta-sheet. PMID: 21539773
    4. nmr analysis of the solution structure of the FHA domain of human Ki67 and mapping of the binding surface for NIFK binding PMID: 14659764
    5. Better basal gene expression was observed by co-cultured respiratory epithelial cells compared to dispase dissociated cells. PMID: 17891046

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  • 亚细胞定位：
    Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.
  • 数据库链接：

    HGNC: 17838

    OMIM: 611970

    KEGG: hsa:84365

    STRING: 9606.ENSP00000285814

    UniGene: Hs.367842