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  4. Recombinant Human MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)

Recombinant Human MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)

  • 中文名称：
    人NIFK重组蛋白
  • 货号：
    CSB-YP887161HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NIFK重组蛋白
  • 货号：
    CSB-EP887161HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NIFK重组蛋白
  • 货号：
    CSB-EP887161HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NIFK重组蛋白
  • 货号：
    CSB-BP887161HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NIFK重组蛋白
  • 货号：
    CSB-MP887161HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NIFK
  • Uniprot No.：
  • 别名：
    hNIFK; MK67I_HUMAN; MKI67 FHA Domain Interacting Nucleolar Phosphoprotein; MKI67 FHA domain-interacting nucleolar phosphoprotein; mki67ip; NOPP34; Nucleolar phosphoprotein Nopp34; Nucleolar protein interacting with the FHA domain of pKI 67; Nucleolar protein interacting with the FHA domain of pKI-67; pKi67
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-293
  • 氨基酸序列
    ATFSGPAGP ILSLNPQEDV EFQKEVAQVR KRITQRKKQE QLTPGVVYVR HLPNLLDETQ IFSYFSQFGT VTRFRLSRSK RTGNSKGYAF VEFESEDVAK IVAETMNNYL FGERLLECHF MPPEKVHKEL FKDWNIPFKQ PSYPSVKRYN RNRTLTQKLR MEERFKKKER LLRKKLAKKG IDYDFPSLIL QKTESISKTN RQTSTKGQVL RKKKKKVSGT LDTPEKTVDS QGPTPVCTPT FLERRKSQVA ELNDDDKDDE IVFKQPISCV KEEIQETQTP THSRKKRRRS SNQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. NIFK is required for lung cancer progression via the RUNX1-dependent CK1alpha repression, which activates TCF4/beta-catenin signaling in metastasis and the Ki-67-dependent regulation in cell proliferation. PMID: 26984280
    2. The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression. PMID: 25826659
    3. Potential encounter complexes of the Ki67FHA receptor and hNIFK peptide are misregistered states of the beta-sheet. PMID: 21539773
    4. nmr analysis of the solution structure of the FHA domain of human Ki67 and mapping of the binding surface for NIFK binding PMID: 14659764
    5. Better basal gene expression was observed by co-cultured respiratory epithelial cells compared to dispase dissociated cells. PMID: 17891046

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  • 亚细胞定位：
    Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.
  • 数据库链接：

    HGNC: 17838

    OMIM: 611970

    KEGG: hsa:84365

    STRING: 9606.ENSP00000285814

    UniGene: Hs.367842