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Phospho-RASGRF1 (Ser916) Antibody

  • 中文名称：
    磷酸化-RASGRF1 (Ser916)兔多克隆抗体
  • 货号：
    CSB-PA256747
  • 规格：
    ￥2454
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human brain tissue using Ras-GRF1 (Phospho-Ser916) antibody (left)or the same antibody preincubated with blocking peptide (right).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) RASGRF1 Polyclonal antibody
  • Uniprot No.：
    Q13972
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of Serine 916(N-E-G(p)-T P) derived from Human Ras-GRF1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes the exchange of Ras-bound GDP by GTP.
  • 基因功能参考文献：
    1. Low RASGRF1 expression due to hypermethylation is associated with Colorectal Cancer. PMID: 29530990
    2. Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia. PMID: 29793445
    3. genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population. PMID: 29044055
    4. Endoplasmic reticulum stress triggers a localized signaling module on the ER surface involving Nox4-dependent calcium mobilization, which directs local Ras activation through ER-associated, calcium-responsive RasGRF. PMID: 27856453
    5. Data show that microRNA miR-137 directly recognized the 3'-UTR (3'-untranslated region) of the RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1) transcript and regulated RASGRF1 expression. PMID: 26440052
    6. Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. PMID: 26521038
    7. Carriers of the rs8027411 G allele in the RASGRF1 gene may be at a lower risk of high myopia in Chinese and Japanese populations. (Meta-analysis) PMID: 26644762
    8. Rasgrf-1 is a novel GEF protein that has a role in BCR signaling and its overexpression further activates the Ras/Erk/MAPK pathway in CLL specimens. PMID: 24597981
    9. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia. PMID: 23834555
    10. CARD9 regulates H-Ras activation by linking Ras-GRF1 to H-Ras, which mediates Dectin-1-induced extracellular signal-regulated protein kinase (ERK) activation and proinflammatory responses when stimulated by their ligands. PMID: 25267792
    11. ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia. PMID: 24150758
    12. Decreased expression of Ras-GRF1 could be involved in the pathogenesis of human temporal lobe epilepsy. PMID: 23200899
    13. Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer. PMID: 22961779
    14. RasGRF1 plays an important role in alveolar rhabdomyosarcoma pathogenesis PMID: 22752028
    15. Demonstrate a role for RasGRF1/2 as negative regulators of Cdc42 activation, suppressing tumor cell movement, cytoskeletal dynamics and cell transformation. PMID: 21685891
    16. Single Nucleotide Polymorphisms in RASGRF1 is associated with refractive errors and myopia. PMID: 20835236
    17. Farnesylated or geranylgeranylated TC21 can be activated by RasGRF1 due to its pleckstrin homology 1 domain, by a mechanism independent of localization & of its ability to associate to membranes. PMID: 19692568
    18. RasGRF family exchange factors, both endogenous and ectopically expressed, are present in the endoplasmic reticulum but not in the Golgi complex PMID: 14749369
    19. Taken together our results demonstrate that U2AF35a is essential for HeLa cell division and suggest a novel role for both U2AF35 protein isoforms as regulators of alternative splicing of a specific subset of genes. PMID: 16855028
    20. Vitamin K3 inhibitor H32 differentially inhibited growth of normal and liver tumor cells by preferentially inhibiting the actions of Cdc25 phosphatases PMID: 16969075
    21. Rasgrf1 transgenic repeats serve at least two functions: first, to establish Rasgrf1 DNA methylation in the male germ line, and second, to resist global demethylation in the preimplantation embryo. PMID: 17030618
    22. zoledronate induces DNA damage and S phase arrest, accompanied by activation of the ATM/Chk1/cdc25 pathway in a human osteosarcoma cell line PMID: 17611684
    23. Enhanced expression and post-translational modification of RasGRF1 contributes to MMP-3 production in RA PMID: 19678938

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  • 数据库链接：

    HGNC: 9875

    OMIM: 606600

    KEGG: hsa:5923

    STRING: 9606.ENSP00000405963

    UniGene: Hs.459035