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  4. Phospho-RGS16 (Y168) Antibody

Phospho-RGS16 (Y168) Antibody

  • 中文名称：
    磷酸化-RGS16 (Y168)兔多克隆抗体
  • 货号：
    CSB-PA040215
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    O15492
  • 基因名：
    RGS16
  • 别名：
    A28 RGS14 antibody; A28 RGS14P antibody; A28-RGS14P antibody; HGNC:9997 antibody; hRGS-r antibody; OTTHUMP00000033147 antibody; Regulator of G protein signaling 16 antibody; Regulator of G protein signalling 16 antibody; Regulator of G-protein signaling 16 antibody; Retinal-specific RGS antibody; Retinally abundant regulator of G protein signaling antibody; Retinally abundant regulator of G-protein signaling antibody; RGS 16 antibody; RGS R antibody; RGS-R antibody; Rgs14 antibody; RGS16 antibody; RGS16_HUMAN antibody; RGSR antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat,Monkey
  • 免疫原：
    Synthesized peptide derived from Human RGS16 around the phosphorylation site of Y168.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals.
  • 基因功能参考文献：
    1. Data suggest that RGS16 functions as a GAP (GTPase accelerating protein) in the SCN (suprachiasmatic nucleus) and is required for circadian timing. [REVIEW] PMID: 28502923
    2. The data establish miR-181a as an oncomiR that promotes chondrosarcoma progression through a new mechanism involving enhancement of CXCR4 signaling by inhibition of RGS16. PMID: 26013170
    3. suggest that deltaEF1 family proteins promote cell motility of breast cancer cells directly or indirectly through repressing expression of RGS16 PMID: 26823172
    4. these results indicate that RGS16 restricts the activation-induced pro-inflammatory profile in myeloid cells. PMID: 25366993
    5. Data indicate that multiplex ligation-dependent probe amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2, RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number gains and 5 % tumour samples with copy number losses. PMID: 23248035
    6. cotreatment with RGS16 siRNA reversed the downregulation of nuclear factor-kappaB expression induced by combined inhibition of LSD1 and HDACs, suggesting a crucial role of RGS16 in controlling key pathways of cell death in response to combination therapy. PMID: 23354309
    7. Missense mutations in RGS16 gene is associated with breast cancer. PMID: 21135262
    8. RGS16 and FosB are underexpressed in pancreatic cancer with lymph node metastasis and associated with reduced survival PMID: 20571966
    9. Increased RGS16 levels are associated with colorectal cancer. PMID: 19760045
    10. Src mediates RGS16 tyrosine phosphorylation, which may promote RGS16 stability. PMID: 12588871
    11. results suggest that the amino-terminal palmitoylation of regulator of G-protein signaling 16 protein(RGS16) promotes its lipid raft targeting that allows palmitoylation of a poorly accessible cysteine residue PMID: 12642593
    12. RGS16 inhibits G alpha 13-mediated, RhoA-dependent reversal of stellation and Serum Response Element activation, thus regulating G alpha 13-mediated signal transduction independently of the RGS box. PMID: 14634662
    13. RGS16 is a negative regulator of SDF-1-CXCR4 signaling in megakaryocytes PMID: 15998835
    14. G alpha(i2) is specifically localized in human Fallopian tube epithelial cells, particularly in cilia, & is likely to have cilia-specific role in reproduction. PMID: 17347170
    15. B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q). PMID: 17613536
    16. Regulator of G Signaling 16 has a role in the distinct endoplasmic reticulum stress state associated with aggregated mutant alpha1-antitrypsin Z in the classical form of alpha1-antitrypsin deficiency PMID: 17635928
    17. The promoter region of RGS16 was found to be methylated in 10% human breast carcinomas PMID: 18521847
    18. the loss of RGS16 in some breast tumors enhances PI3K signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation PMID: 19509421

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  • 亚细胞定位：
    Membrane; Lipid-anchor.
  • 组织特异性：
    Abundantly expressed in retina with lower levels of expression in most other tissues.
  • 数据库链接：

    HGNC: 9997

    OMIM: 602514

    KEGG: hsa:6004

    STRING: 9606.ENSP00000356529

    UniGene: Hs.413297