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Phospho-STMN2 (S73) Antibody

  • 中文名称：
    磷酸化-STMN2 (S73)兔多克隆抗体
  • 货号：
    CSB-PA006764
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q93045
  • 基因名：
    STMN2
  • 别名：
    Neuron specific growth associated protein antibody; Neuronal growth associated protein antibody; Neuronal growth associated protein (silencer element) antibody; Protein SCG10 antibody; SCG 10 antibody; SCG10 antibody; SCG10 protein antibody; SCGN 10 antibody; SCGN10 antibody; SGC 10 antibody; SGC10 antibody; Stathmin 2 antibody; Stathmin like 2 antibody; Stathmin-2 antibody; STMN 2 antibody; STMN2 antibody; STMN2_HUMAN antibody; Superior cervical ganglia neural specific 10 antibody; Superior cervical ganglion 10 protein antibody; Superior cervical ganglion-10 protein antibody; Superiorcervical ganglia neural specific 10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human SCG10 around the phosphorylation site of S73.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
  • 基因功能参考文献：
    1. RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population. PMID: 24414001
    2. STMN and SCG10 are similarly targeted by JNK but there are clear differences in JNK recognition and phosphorylation of the closely related family member, SCLIP. PMID: 24589734
    3. SCG10 is upregulated in the IKAP/Elp1-deficient familial dysautonomia cerebrum lending support to the concept that SCG10 elevation can alter the microtubule organization and dynamics PMID: 21273291
    4. Overexpression of SCG10 is associated with Liver Fibrosis. PMID: 20802173
    5. RGS6 interacts with this protein and promotes neuronal differentiation; role of the G gamma subunit-like (GGL) domain of RGS6 PMID: 12140291
    6. STMN2 is required for maintaining the anchorage-independent growth state of beta-catenin/TCF-activated hepatoma cells PMID: 16712787
    7. activity at opposite microtubule ends may play role role in regulating growth cone microtubules; ability to promote plus end growth may facilitate microtubule extension; ability to destabilize minus ends may provide tubulin for net plus end elongation PMID: 17311410
    8. Review proposes a model reconciling the microtubule regulatory properties of superior cervical ganglion protein 10 with its role as a c-Jun N-terminal kinase 1 (JNK1) effector of regeneration. PMID: 18076368
    9. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. PMID: 18452648
    10. SCLIP and SCG10 were colocalized to the Golgi apparatus of chromaffin cells in vivo and shared localization with CHGA as it transited the Golgi. PMID: 18549247
    11. STMN2 appears a novel marker of osteogenesis and osteoblast per se, that could play a role in the regulation of the adipocyte/osteoblast balance. PMID: 18611392
    12. SCG10 acts as an effector downstream of Rnd1 to regulate axon extensions by modulating microtubule organization. PMID: 18996843

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Golgi apparatus. Endosome. Cell projection, lamellipodium.
  • 蛋白家族：
    Stathmin family
  • 组织特异性：
    Neuron specific.
  • 数据库链接：

    HGNC: 10577

    OMIM: 600621

    KEGG: hsa:11075

    STRING: 9606.ENSP00000429243

    UniGene: Hs.521651