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Pklr Antibody

  • 货号：
    CSB-PA018071LA01RA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Pklr antibody at 2µg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 63, 59 kDa
      Observed band size: 63 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Pklr Polyclonal antibody
  • Uniprot No.：
    P12928
  • 基因名：
  • 别名：
    PklrPyruvate kinase PKLR antibody; EC 2.7.1.40 antibody; L-PK antibody; Pyruvate kinase isozymes L/R antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat, Human
  • 免疫原：
    Recombinant Rat Pyruvate kinase PKLR protein (1-574AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Pklr Antibody (CSB-PA018071LA01RA)，的标记方式是Non-conjugated。对于Pklr Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA018071LB01RA Pklr Antibody, HRP conjugated ELISA
    FITC CSB-PA018071LC01RA Pklr Antibody, FITC conjugated
    Biotin CSB-PA018071LD01RA Pklr Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a key role in glycolysis.
  • 基因功能参考文献：
    1. Studied the effect of the point mutations around this phosphorylation site on the catalytic properties of L-pyruvate kinase. PMID: 22878931
    2. c-Myc is required for the glucose-mediated induction of this metabolic enzyme. PMID: 12480946
    3. We observed that cystine inhibited the enzyme pyruvate kinase activity non-competitively in a dose- and time-dependent way. PMID: 15196592
    4. cooperative interaction between NF1 family members and HNF1alpha plays an important role in hepatic L-PK transcription PMID: 16204235
    5. Regulation of hepatic L-pyruvate kinase promoter composition and activity PMID: 16644726
    6. A novel chimeric promoter, consisting of a 1.6 kb glucose 6-phosphatase promoter and a segment of the regulatory element derived from the L-type pyruvate kinase promoter, was designed to provide strong and tight control of insulin expression in liver. PMID: 17160355
    7. Maximal glucose-induced expression of the L-PK gene in INS-1-derived 832/13 cells involves increased c-Myc abundance, recruitment of c-Myc, Max, and ChREBP to the promoter, and a glucose-stimulated increase in ChREBP transactivation. PMID: 17341548
    8. A detailed analysis of the molecular events of the insulin-independent glucose response of the liver-type pyruvate kinase (L-PK) gene was performed. PMID: 18468514
    9. cAMP and glucose signaling converge on a complex containing ChREBP, HNF4alpha, and CBP, and cAMP acts by disrupting this transcriptional complex assembled by glucose-derived signals PMID: 19406844
    10. Data show that glucose regulates acetylation and methylation of various histone residues at the L-PK gene promoter. PMID: 19631660

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  • 蛋白家族：
    Pyruvate kinase family
  • 数据库链接：

    KEGG: rno:24651

    STRING: 10116.ENSRNOP00000027700

    UniGene: Rn.48821