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RNF144A Antibody

  • 中文名称：
    RNF144A兔多克隆抗体
  • 货号：
    CSB-PA004357
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using UBCE7IP4 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P50876
  • 基因名：
    RNF144A
  • 别名：
    RNF144A; KIAA0161; RNF144; UBCE7IP4; E3 ubiquitin-protein ligase RNF144A; RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human UBCE7IP4.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.
  • 基因功能参考文献：
    1. both proper membrane localization and self-association are important for RNF144A function. PMID: 26216882
    2. The regulation of DNA-PKcs by RNF144A is important for proper apoptotic response during DNA damage, suggesting a tumor suppressor function for RNF144A. PMID: 24979766
    3. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
    4. Functional analysis of the mouse counterpart. PMID: 10431818
  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
  • 蛋白家族：
    RBR family, RNF144 subfamily
  • 数据库链接：

    HGNC: 20457

    KEGG: hsa:9781

    STRING: 9606.ENSP00000321330

    UniGene: Hs.22146