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S100A13 Antibody

  • 中文名称：
    S100A13兔多克隆抗体
  • 货号：
    CSB-PA179416
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA179416(S100A13 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA179416(S100A13 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q99584
  • 基因名：
    S100A13
  • 别名：
    Protein S100 A13 antibody; Protein S100-A13 antibody; S100 calcium binding protein A13 antibody; S100 calcium-binding protein A13 antibody; S100a13 antibody; S10AD_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human S100A13
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
  • 基因功能参考文献：
    1. This is the first report for the association between HMGA1 and S100A13 expression in the modulation of thyroid cancer growth and invasion. PMID: 27008379
    2. S100A13 interacts with the C2 domain of RAGE. PMID: 24982031
    3. S100A13 is involved in cutaneous malignant melanoma resistance to DTIC/TMZ. PMID: 24722184
    4. the IL1alpha-S100A13 tetrameric complex is the key complex formed during the non-classical pathway of IL1alpha release PMID: 21270123
    5. S100A13 promotes the release of FGF-1 protein, but does not affect the transportation of FGF-1 protein in human umbilical vein endothelial cells. PMID: 20863990
    6. S100A13 is expressed in melanocytic lesions when the angiogenic switch occurs and it may cooperate with VEGF-A in supporting the formation of new blood vessels, favoring the shift from radial to vertical tumor growth. PMID: 20208480
    7. detected in both cells and fibers of the hippocampus at 12 weeks gestation, slightly stronger at 20 weeks, and then decreased with age. In the temporal cortex, strong in all cellular layers at 12 to 24 weeks, declined with age from 28 weeks onwards. PMID: 12645008
    8. Stress-induced export of IL-1alpha involves the intracellular association with the Cu2+-binding protein, S100A13; the expression of a S100A13 mutant functions as a dominant-negative repressor of IL-1alpha release. PMID: 12746488
    9. S100A13 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells PMID: 15033494
    10. data show that the expression of endoglin and S100A13 protein corresponds to the activation of the endothelial cells in the process of endometriotic angiogenesis PMID: 15821778
    11. In human astrocytic gliomas, S100A13 was significantly up-regulated in high-grade vascularized gliomas. Moreover, S100A13 expression significantly correlated with microvessel density and tumour grading. PMID: 16773219
    12. Human S100A13 was heterologously expressed in Escherichia coli, purified and crystallized by the hanging-drop vapour-diffusion method. PMID: 17077500
    13. S100A13 is a homodimer with four EF-hand motifs in an asymmetric unit, displaying a folding pattern similar to other S100 members. S100A13 has the unique structural feature with all alpha-helices being amphiphilic. PMID: 17374362
    14. Despite the high similarity of the backbone conformation in each protomer, the crystal structures of human S100A13 at pH 7.5 and at pH 6.0 exhibit recognizable differences in the relative orientation of the protomers within the dimer PMID: 18259052

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  • 亚细胞定位：
    Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions.
  • 蛋白家族：
    S-100 family
  • 组织特异性：
    Expressed in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 10490

    OMIM: 601989

    KEGG: hsa:6284

    STRING: 9606.ENSP00000344822

    UniGene: Hs.516505