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  4. Recombinant Human Protein S100-A13 (S100A13)

Recombinant Human Protein S100-A13 (S100A13)

  • 中文名称：
    人S100A13重组蛋白
  • 货号：
    CSB-YP859514HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人S100A13重组蛋白
  • 货号：
    CSB-EP859514HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人S100A13重组蛋白
  • 货号：
    CSB-EP859514HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人S100A13重组蛋白
  • 货号：
    CSB-BP859514HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人S100A13重组蛋白
  • 货号：
    CSB-MP859514HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    S100A13
  • Uniprot No.：
  • 别名：
    Protein S100 A13; Protein S100-A13; S100 calcium binding protein A13; S100 calcium-binding protein A13; S100a13; S10AD_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-98
  • 氨基酸序列
    MAAEPLTELE ESIETVVTTF FTFARQEGRK DSLSVNEFKE LVTQQLPHLL KDVGSLDEKM KSLDVNQDSE LKFNEYWRLI GELAKEIRKK KDLKIRKK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine.
  • 基因功能参考文献：
    1. This is the first report for the association between HMGA1 and S100A13 expression in the modulation of thyroid cancer growth and invasion. PMID: 27008379
    2. S100A13 interacts with the C2 domain of RAGE. PMID: 24982031
    3. S100A13 is involved in cutaneous malignant melanoma resistance to DTIC/TMZ. PMID: 24722184
    4. the IL1alpha-S100A13 tetrameric complex is the key complex formed during the non-classical pathway of IL1alpha release PMID: 21270123
    5. S100A13 promotes the release of FGF-1 protein, but does not affect the transportation of FGF-1 protein in human umbilical vein endothelial cells. PMID: 20863990
    6. S100A13 is expressed in melanocytic lesions when the angiogenic switch occurs and it may cooperate with VEGF-A in supporting the formation of new blood vessels, favoring the shift from radial to vertical tumor growth. PMID: 20208480
    7. detected in both cells and fibers of the hippocampus at 12 weeks gestation, slightly stronger at 20 weeks, and then decreased with age. In the temporal cortex, strong in all cellular layers at 12 to 24 weeks, declined with age from 28 weeks onwards. PMID: 12645008
    8. Stress-induced export of IL-1alpha involves the intracellular association with the Cu2+-binding protein, S100A13; the expression of a S100A13 mutant functions as a dominant-negative repressor of IL-1alpha release. PMID: 12746488
    9. S100A13 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells PMID: 15033494
    10. data show that the expression of endoglin and S100A13 protein corresponds to the activation of the endothelial cells in the process of endometriotic angiogenesis PMID: 15821778
    11. In human astrocytic gliomas, S100A13 was significantly up-regulated in high-grade vascularized gliomas. Moreover, S100A13 expression significantly correlated with microvessel density and tumour grading. PMID: 16773219
    12. Human S100A13 was heterologously expressed in Escherichia coli, purified and crystallized by the hanging-drop vapour-diffusion method. PMID: 17077500
    13. S100A13 is a homodimer with four EF-hand motifs in an asymmetric unit, displaying a folding pattern similar to other S100 members. S100A13 has the unique structural feature with all alpha-helices being amphiphilic. PMID: 17374362
    14. Despite the high similarity of the backbone conformation in each protomer, the crystal structures of human S100A13 at pH 7.5 and at pH 6.0 exhibit recognizable differences in the relative orientation of the protomers within the dimer PMID: 18259052

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  • 亚细胞定位：
    Cytoplasm. Secreted. Note=Secretion is mediated by exposure to stress and requires copper ions.
  • 蛋白家族：
    S-100 family
  • 组织特异性：
    Expressed in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 10490

    OMIM: 601989

    KEGG: hsa:6284

    STRING: 9606.ENSP00000344822

    UniGene: Hs.516505