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  4. SAT2 Antibody

SAT2 Antibody

  • 货号：
    CSB-PA020718GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q96F10
  • 基因名：
    SAT2
  • 别名：
    Amino acid transporter A2 antibody; ATA2 antibody; Diamine acetyltransferase 2 antibody; Diamine N acetyltransferase 2 antibody; Polyamine N acetyltransferase antibody; Polyamine N-acetyltransferase 2 antibody; Protein 40 9 1 antibody; SAT2 antibody; SAT2_HUMAN antibody; SNAT2 antibody; Solute carrier family 38 member 2 antibody; Spermidine/spermine N(1)-acetyltransferase 2 antibody; Spermidine/spermine N1 acetyltransferase 2 antibody; Spermidine/spermine N1 acetyltransferase family member 2 antibody; SSAT2 antibody; System A amino acid transporter 2 antibody; System A transporter 1 antibody; System N amino acid transporter 2 antibody; Thialysine N-epsilon-acetyltransferase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SAT2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine. However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo.
  • 基因功能参考文献：
    1. Crystallization of this protein and its recombinant form and its complexation with coenzyme A. PMID: 16596569
    2. The expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated. PMID: 17119850
    3. SSAT2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha PMID: 17558023
    4. SSAT1, which shares 46% amino acid identity with SSAT2, also binds to HIF-1alpha and promotes its ubiquitination/degradation. However, in contrast to SSAT2, SSAT1 acts by stabilizing the interaction of HIF-1alpha with RACK1 PMID: 17875644
    5. expression of SSAT mediated by Ad-SSAT infection inhibits the growth of colorectal cancer cells PMID: 18949426

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Acetyltransferase family
  • 组织特异性：
    Widely expressed. Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2.
  • 数据库链接：

    HGNC: 23160

    OMIM: 611463

    KEGG: hsa:112483

    STRING: 9606.ENSP00000269298

    UniGene: Hs.10846