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  4. Recombinant Human Diamine acetyltransferase 2 (SAT2)

Recombinant Human Diamine acetyltransferase 2 (SAT2)

  • 中文名称：
    人SAT2重组蛋白
  • 货号：
    CSB-YP836208HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SAT2重组蛋白
  • 货号：
    CSB-EP836208HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SAT2重组蛋白
  • 货号：
    CSB-EP836208HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SAT2重组蛋白
  • 货号：
    CSB-BP836208HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SAT2重组蛋白
  • 货号：
    CSB-MP836208HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SAT2
  • Uniprot No.：
  • 别名：
    Amino acid transporter A2; ATA2; Diamine acetyltransferase 2; Diamine N acetyltransferase 2; Polyamine N acetyltransferase; Polyamine N-acetyltransferase 2; Protein 40 9 1; SAT2; SAT2_HUMAN; SNAT2; Solute carrier family 38 member 2; Spermidine/spermine N(1)-acetyltransferase 2; Spermidine/spermine N1 acetyltransferase 2; Spermidine/spermine N1 acetyltransferase family member 2; SSAT2; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2; Thialysine N-epsilon-acetyltransferase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-170
  • 氨基酸序列
    MASVRIREAK EGDCGDILRL IRELAEFEKL SDQVKISEEA LRADGFGDNP FYHCLVAEIL PAPGKLLGPC VVGYGIYYFI YSTWKGRTIY LEDIYVMPEY RGQGIGSKII KKVAEVALDK GCSQFRLAVL DWNQRAMDLY KALGAQDLTE AEGWHFFCFQ GEATRKLAGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine. However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo.
  • 基因功能参考文献：
    1. Crystallization of this protein and its recombinant form and its complexation with coenzyme A. PMID: 16596569
    2. The expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated. PMID: 17119850
    3. SSAT2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha PMID: 17558023
    4. SSAT1, which shares 46% amino acid identity with SSAT2, also binds to HIF-1alpha and promotes its ubiquitination/degradation. However, in contrast to SSAT2, SSAT1 acts by stabilizing the interaction of HIF-1alpha with RACK1 PMID: 17875644
    5. expression of SSAT mediated by Ad-SSAT infection inhibits the growth of colorectal cancer cells PMID: 18949426

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Acetyltransferase family
  • 组织特异性：
    Widely expressed. Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2.
  • 数据库链接：

    HGNC: 23160

    OMIM: 611463

    KEGG: hsa:112483

    STRING: 9606.ENSP00000269298

    UniGene: Hs.10846