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SERTAD1 Antibody

  • 货号：
    CSB-PA883406LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: SERTAD1 antibody at 6μg/ml
      Lane 1: SH-SY5Y whole cell lysate
      Lane 2: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 25 kDa
      Observed band size: 25 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA883406LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA883406LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) SERTAD1 Polyclonal antibody
  • Uniprot No.：
    Q9UHV2
  • 基因名：
    SERTAD1
  • 别名：
    CDK4 binding protein p34SEI antibody; CDK4 binding protein p34SEI1 antibody; CDK4-binding protein p34SEI1 antibody; SEI-1 antibody; SEI1 antibody; SERTA domain containing 1 antibody; SERTA domain-containing protein 1 antibody; SERTAD1 antibody; SRTD1_HUMAN antibody; Transcriptional regulator interacting with the PHD-bromodomain 1 antibody; TRIP Br1 antibody; TRIP-Br1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human SERTA domain-containing protein 1 protein (1-236AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，SERTAD1 Antibody (CSB-PA883406LA01HU)，的标记方式是Non-conjugated。对于SERTAD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA883406LB01HU SERTAD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA883406LC01HU SERTAD1 Antibody, FITC conjugated
    Biotin CSB-PA883406LD01HU SERTAD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
  • 基因功能参考文献：
    1. Here, the s show that transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1, Sertad1), a newly identified protein with poorly characterized functions, acts as an adaptor that bridges the interaction of multiple Adenylyl cyclase isoforms with X-linked inhibitor of apoptosis protein (XIAP), a RING-domain E3 ubiquitin ligase. PMID: 28656888
    2. NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1. Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 are identified by NMR titration experiments. PMID: 28666866
    3. SEI1 up-regulation induces genomic instability by inhibiting DNA damage response in ovarian cancer cells. PMID: 27697611
    4. Findings provide evidence that TRIP-Br1 functions as an oncogenic protein by providing cancer cells resistance to the hypoxia-induced cell death of breast cancer cells. PMID: 27035851
    5. TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production. PMID: 26334958
    6. Data demonstrate that p34SEI-1 induces the activation of either AKT or ILK signaling on HER2/neu expression status. PMID: 24789658
    7. High SERTAD1 expression is associated with breast cancer. PMID: 23970032
    8. These results suggest that p34 (SEI-1) inhibits ROS-induced cell death through by indirectly inducing ubiquitination of ASK1. PMID: 21725208
    9. study shows that the p34SE1-1 expression level was not changed after H2O2 treatment at either protein or transcriptional levels PMID: 21344158
    10. Translocation of small amount of NM23H1 into the nucleus induced by the overexpressions of SEI1/SET could increase the frequency of sister chromatid exchangein esophageal cancers. PMID: 20570897
    11. p34SEI-1 strongly suppressed CREB-mediated transcription, and this suppression was overcome by excess amount of CBP PMID: 12736710
    12. interacts with low- and high-risk HPV11 and HPV16 E6 proteins in yeast, in vitro and in mammalian cell cultures PMID: 14675634
    13. p34SEI1 fragment 30-160 can bind, activate, and inhibit cyclin-dependent kinase CDK4; fragment 30-132 binds and activates but does not inhibit CDK4, while fragment 30-88 cannot bind, activate, or inhibit but retains LexA-mediated transactivation activity. PMID: 15065884
    14. p34(SEI-1) and p16(INK4A) have different roles in development of squamous cell carcinoma of the head and neck PMID: 16201750

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  • 数据库链接：

    HGNC: 17932

    OMIM: 617850

    KEGG: hsa:29950

    STRING: 9606.ENSP00000350633

    UniGene: Hs.269898