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  4. Recombinant Human SERTA domain-containing protein 1 (SERTAD1)

Recombinant Human SERTA domain-containing protein 1 (SERTAD1)

  • 中文名称：
    人SERTAD1重组蛋白
  • 货号：
    CSB-YP883406HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SERTAD1重组蛋白
  • 货号：
    CSB-EP883406HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SERTAD1重组蛋白
  • 货号：
    CSB-EP883406HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SERTAD1重组蛋白
  • 货号：
    CSB-BP883406HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SERTAD1重组蛋白
  • 货号：
    CSB-MP883406HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SERTAD1
  • Uniprot No.：
  • 别名：
    CDK4 binding protein p34SEI; CDK4 binding protein p34SEI1; CDK4-binding protein p34SEI1; SEI-1; SEI1; SERTA domain containing 1; SERTA domain-containing protein 1; SERTAD1; SRTD1_HUMAN; Transcriptional regulator interacting with the PHD-bromodomain 1; TRIP Br1; TRIP-Br1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-236
  • 氨基酸序列
    MLSKGLKRKR EEEEEKEPLA VDSWWLDPGH TAVAQAPPAV ASSSLFDLSV LKLHHSLQQS EPDLRHLVLV VNTLRRIQAS MAPAAALPPV PSPPAAPSVA DNLLASSDAA LSASMASLLE DLSHIEGLSQ APQPLADEGP PGRSIGGAAP SLGALDLLGP ATGCLLDDGL EGLFEDIDTS MYDNELWAPA SEGLKPGPED GPGKEEAPEL DEAELDYLMD VLVGTQALER PPGPGR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.
  • 基因功能参考文献：
    1. Here, the s show that transcriptional regulator interacting with the PHD-bromodomain 1 (TRIP-Br1, Sertad1), a newly identified protein with poorly characterized functions, acts as an adaptor that bridges the interaction of multiple Adenylyl cyclase isoforms with X-linked inhibitor of apoptosis protein (XIAP), a RING-domain E3 ubiquitin ligase. PMID: 28656888
    2. NEDD4-1 recognizes SERTA domain containing proline rich region of p34SEI-1. Residues of NEDD4-1 responsible for direct interaction with p34SEI-1 are identified by NMR titration experiments. PMID: 28666866
    3. SEI1 up-regulation induces genomic instability by inhibiting DNA damage response in ovarian cancer cells. PMID: 27697611
    4. Findings provide evidence that TRIP-Br1 functions as an oncogenic protein by providing cancer cells resistance to the hypoxia-induced cell death of breast cancer cells. PMID: 27035851
    5. TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production. PMID: 26334958
    6. Data demonstrate that p34SEI-1 induces the activation of either AKT or ILK signaling on HER2/neu expression status. PMID: 24789658
    7. High SERTAD1 expression is associated with breast cancer. PMID: 23970032
    8. These results suggest that p34 (SEI-1) inhibits ROS-induced cell death through by indirectly inducing ubiquitination of ASK1. PMID: 21725208
    9. study shows that the p34SE1-1 expression level was not changed after H2O2 treatment at either protein or transcriptional levels PMID: 21344158
    10. Translocation of small amount of NM23H1 into the nucleus induced by the overexpressions of SEI1/SET could increase the frequency of sister chromatid exchangein esophageal cancers. PMID: 20570897
    11. p34SEI-1 strongly suppressed CREB-mediated transcription, and this suppression was overcome by excess amount of CBP PMID: 12736710
    12. interacts with low- and high-risk HPV11 and HPV16 E6 proteins in yeast, in vitro and in mammalian cell cultures PMID: 14675634
    13. p34SEI1 fragment 30-160 can bind, activate, and inhibit cyclin-dependent kinase CDK4; fragment 30-132 binds and activates but does not inhibit CDK4, while fragment 30-88 cannot bind, activate, or inhibit but retains LexA-mediated transactivation activity. PMID: 15065884
    14. p34(SEI-1) and p16(INK4A) have different roles in development of squamous cell carcinoma of the head and neck PMID: 16201750

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  • 数据库链接：

    HGNC: 17932

    OMIM: 617850

    KEGG: hsa:29950

    STRING: 9606.ENSP00000350633

    UniGene: Hs.269898