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SH3KBP1 Antibody

  • 货号：
    CSB-PA160205
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA160205(SH3KBP1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q96B97
  • 基因名：
  • 别名：
    c Cbl interacting protein antibody; Cbl interacting protein antibody; Cbl interacting protein of 85 kDa antibody; Cbl-interacting protein of 85 kDa antibody; CD2 binding protein 3 antibody; CD2-binding protein 3 antibody; CD2BP3 antibody; CIN 85 antibody; CIN85 antibody; GIG 10 antibody; GIG10 antibody; HSB 1 antibody; HSB-1 antibody; HSB1 antibody; Human Src family kinase binding protein 1 antibody; Human Src family kinase-binding protein 1 antibody; MIG 18 antibody; MIG18 antibody; Migration inducing gene 18 antibody; Migration inducing gene 18 protein antibody; SH3 domain kinase binding protein 1 antibody; SH3 domain-containing kinase-binding protein 1 antibody; SH3BP 1 antibody; SH3K1_HUMAN antibody; SH3KBP1 antibody; Src family kinase binding protein 1 antibody; src related kinase binding protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human SH3KBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory su...显示更多
  • 基因功能参考文献：
    1. The multiple Src homology 3 (SH3) domains of trimeric CIN85 molecules associated with multiple SLP-65 molecules, which recruited further CIN85 trimers, thereby perpetuating the oligomerization process. PMID: 27353366
    2. these data support a role for the novel PP2Ac-CIN85 complex in supporting integrin-dependent platelet function by dampening the phosphatase activity. PMID: 27334924
    3. CIN85 promotes recycling of TGF-beta receptors and thereby positively regulates TGF-beta signaling. PMID: 26169354
    4. Results support the model that Cbl-CIN85-endophilin complex is not required for efficient internalization of EGFR, a prototype RTK. PMID: 25449262
    5. Multiple molecular forms of adaptor protein Ruk/CIN85 specifically associate with different subcellular compartments in human breast adenocarcinoma cell line. PMID: 25816594
    6. LOX-PP interacts with CIN85 via a novel SH3-binding motif and this association reduces CIN85-promoted invasion by breast cancer cells. PMID: 24167568
    7. Data show that EGFR activation leads to a pronounced src-mediated tyrosine phosphorylation of CIN85 that subsequently influences EGFR ubiquitination. PMID: 22833562
    8. this study indicates that high levels of Ruk(l)/CIN85 contribute to the conversion of breast adenocarcinoma cells into a more malignant phenotype via modulation of the Src/Akt pathway. PMID: 22791810
    9. Data show that CIN85 (c-Cbl interacting protein of 85 kDa) is constitutively associated with c-Cbl, Cbl-b, and B-cell linker in B cells. PMID: 22262777
    10. The CIN85 was constitutively associated with Hrs, and this strengthens the hypothesis of a functional role of CIN85 in endosomal EGFR sorting. PMID: 21635887
    11. the ubiquitination and degradation of stimulated FcgammaRIIa mediated by c-Cbl are positively regulated by the adaptor protein CIN85 in a PKC-dependent manner and these events contribute to the termination of FcgammaRIIa signaling. PMID: 21372129
    12. the N- and C-termini are important for the structure, stability, and function of the third SH3 domain of CIN85 PMID: 21446695
    13. ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking. PMID: 21275903
    14. High CIN85 is associated with the development and progression of head and neck squamous cell carcinoma. PMID: 20927317
    15. CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4 PMID: 20221403
    16. Ruk/CIN85 induces PAI-1 expression via modulation of HIF-1alpha stability PMID: 20216986
    17. The ORF3 protein of hepatitis E virus was found to interact with CIN85 and compete with the formation of the growth factor receptor-Cbl-CIN85 complex, resulting in the reduced ubiquitination of CIN85. PMID: 20130058
    18. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors PMID: 11894095
    19. The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met PMID: 11894096
    20. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases PMID: 12177062
    21. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. PMID: 12218189
    22. Cd2 antigen is linked to CAPZ via this protein and CMS. PMID: 12690097
    23. forms complexes with endonucleases in HEK293 cells PMID: 12946264
    24. CIN85 association with Dab2 is essential for its recruitment to clathrin coat and appears to be modulated by growth factor stimulation PMID: 14596919
    25. Data show that infected cell protein 0 (ICP0) binds CIN85 in a reciprocal manner and that the complexes pulled down by ICP0 also contain Cbl. PMID: 15824310
    26. CIN85 might play an important role in HSV-1 infection. PMID: 16223483
    27. Taken together, these results indicate a novel role for CIN85 in the regulation of cellular stress response via the MAPK pathways. PMID: 16256071
    28. CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery. PMID: 17255943
    29. a new role for CIN85 in regulating Syk protein levels in RBL-2H3 cells through the activation of the ubiquitin-proteasome pathway and provide a mechanism for this regulation involving c-Cbl ligase activity. PMID: 17675467
    30. These results suggest that endogenous Ruk/CIN85 may be involved in regulation of specific membrane trafficking processes. PMID: 18266907
    31. Results suggest that competition between Cbl and ubiquitin binding to CIN85 regulates Cbl function and EGFR endocytosis. PMID: 18680311
    32. Epidermal Growth Factor stimulation increases association of Cbl and Ruk/CIN85, which is dependent on tyrosine phosphorylation of the C-terminal region of Proto-Oncogene Proteins Cbl. PMID: 19166927
    33. detailed high-resolution solution structural study of CIN85A and CIN85B binding to proline-arginine peptides derived from the cognate ligands Cbl and Cbl-b PMID: 19268472
    34. CIN85 (SH3-domain kinase binding protein 1) associates with TNF receptor 1 via Src and modulates TNF-alpha-induced apoptosis. PMID: 15707590

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion.
  • 组织特异性：
    Ubiquitously expressed. Also expressed in some cancer cell lines.
  • 数据库链接：

    HGNC: 13867

    OMIM: 300374

    KEGG: hsa:30011

    STRING: 9606.ENSP00000380921

    UniGene: Hs.726365