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SHKBP1 Antibody

  • 货号：
    CSB-PA021271GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8TBC3
  • 基因名：
  • 别名：
    PP203 antibody; Sb1 antibody; SH3KBP1 binding protein 1 antibody; SH3KBP1-binding protein 1 antibody; SHKB1_HUMAN antibody; SHKBP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SHKBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
  • 基因功能参考文献：
    1. SHKBP1 disturbed the translocation of CIN85 to EGFR-containing vesicles. PMID: 21830225
    2. hSB1 may function as a regulator of cathepsin B-mediated apoptosis. PMID: 16733801
  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    KCTD3 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 19214

    OMIM: 617322

    KEGG: hsa:92799

    STRING: 9606.ENSP00000291842

    UniGene: Hs.26506