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  4. Recombinant Human SH3KBP1-binding protein 1 (SHKBP1)

Recombinant Human SH3KBP1-binding protein 1 (SHKBP1)

  • 中文名称：
    人SHKBP1重组蛋白
  • 货号：
    CSB-YP855040HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人SHKBP1重组蛋白
  • 货号：
    CSB-EP855040HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人SHKBP1重组蛋白
  • 货号：
    CSB-EP855040HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人SHKBP1重组蛋白
  • 货号：
    CSB-BP855040HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人SHKBP1重组蛋白
  • 货号：
    CSB-MP855040HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    PP203; Sb1; SH3KBP1 binding protein 1; SH3KBP1-binding protein 1; SHKB1_HUMAN; SHKBP1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-707
  • 氨基酸序列
    AAAATAAEG VPSRGPPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QLREELDRSS CGNVLFNGYL PPPVFPVKRR NRHSLVGPQQ LGGRPAPVRR SNTMPPNLGN AGLLGRMLDE KTPPSPSGQP EEPGMVRLVC GHHNWIAVAY TQFLVCYRLK EASGWQLVFS SPRLDWPIER LALTARVHGG ALGEHDKMVA AATGSEILLW ALQAEGGGSE IGVFHLGVPV EALFFVGNQL IATSHTGRIG VWNAVTKHWQ VQEVQPITSY DAAGSFLLLG CNNGSIYYVD VQKFPLRMKD NDLLVSELYR DPAEDGVTAL SVYLTPKTSD SGNWIEIAYG TSSGGVRVIV QHPETVGSGP QLFQTFTVHR SPVTKIMLSE KHLISVCADN NHVRTWSVTR FRGMISTQPG STPLASFKIL ALESADGHGG CSAGNDIGPY GERDDQQVFI QKVVPSASQL FVRLSSTGQR VCSVRSVDGS PTTAFTVLEC EGSRRLGSRP RRYLLTGQAN GSLAMWDLTT AMDGLGQAPA GGLTEQELME QLEHCELAPP APSAPSWGCL PSPSPRISLT SLHSASSNTS LSGHRGSPSP PQAEARRRGG GSFVERCQEL VRSGPDLRRP PTPAPWPSSG LGTPLTPPKM KLNETSF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.
  • 基因功能参考文献：
    1. SHKBP1 disturbed the translocation of CIN85 to EGFR-containing vesicles. PMID: 21830225
    2. hSB1 may function as a regulator of cathepsin B-mediated apoptosis. PMID: 16733801
  • 亚细胞定位：
    Lysosome.
  • 蛋白家族：
    KCTD3 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 19214

    OMIM: 617322

    KEGG: hsa:92799

    STRING: 9606.ENSP00000291842

    UniGene: Hs.26506