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SHMT2 Antibody

  • 中文名称：
    SHMT2兔多克隆抗体
  • 货号：
    CSB-PA021274GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P34897
  • 基因名：
    SHMT2
  • 别名：
    Epididymis secretory sperm binding protein Li 51e antibody; GLY A+ antibody; GLYA antibody; glycine auxotroph A; human complement for hamster antibody; Glycine hydroxymethyltransferase antibody; GLYM_HUMAN antibody; HEL S 51e antibody; mitochondrial antibody; Serine hydroxymethyltransferase 2 (mitochondrial) antibody; Serine hydroxymethyltransferase antibody; Serine hydroxymethyltransferase mitochondrial antibody; Serine methylase antibody; SHMT 2 antibody; SHMT antibody; SHMT2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SHMT2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.
  • 基因功能参考文献：
    1. Findings support the hypothesis that age-associated respiration defects in fibroblasts of elderly humans are caused not by mtDNA mutations but by epigenetic regulation of nuclear genes including SHMT2. PMID: 29323231
    2. SHMT2 Desuccinylation is associated with Cancer Cell Proliferation. PMID: 29180469
    3. Our data confirm the heterogeneity of breast tumors at a functional proteomic level and dissects the relationship between metabolism-related proteins, pathological features and patient survival. These observations highlight the importance of SHMT2 and ASCT2 as valuable individual prognostic markers and potential targets for personalized breast cancer therapy PMID: 29020998
    4. Data suggest that serine hydroxymethyltransferase 2 (SHMT2) may be a potential target in the treatment of hepatocellular carcinoma (HCC). PMID: 27391339
    5. High SHMT2 expression is associated with idiopathic pulmonary fibrosis. PMID: 27836973
    6. These results indicate that SHMT2 may be a valuable prognostic biomarker in ER-negative breast cancer cases PMID: 27666119
    7. our results for the first time showed that miR-615-5p prevents proliferation and migration through negatively regulating SHMT2 in HCC. PMID: 26662310
    8. The SHMT-2 is the direct targets of miR-370 and miR-373, respectively, in human articular chondrocytes. PMID: 26103880
    9. High SHMT2 expression increases glycine-dependent nucleotide synthesis leading to bladder cancer growth. PMID: 26975021
    10. SHMT2 is required for glioblastoma multiforme cells to adapt to the tumour environment, but also renders these cells sensitive to glycine cleavage system inhibition PMID: 25855294
    11. This paper compares the mitochondrial and cytoplasmic forms of this enzyme and suggests that the two genes are a result of a single gene duplication. PMID: 9573390

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  • 亚细胞定位：
    Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane. Cytoplasm. Nucleus.
  • 蛋白家族：
    SHMT family
  • 数据库链接：

    HGNC: 10852

    OMIM: 138450

    KEGG: hsa:6472

    STRING: 9606.ENSP00000333667

    UniGene: Hs.741179