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SIM2 Antibody

  • 货号：
    CSB-PA021326GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q14190
  • 基因名：
    SIM2
  • 别名：
    bHLHe15 antibody; Class E basic helix loop helix protein 15 antibody; Class E basic helix-loop-helix protein 15 antibody; MGC119447 antibody; SIM 2 antibody; SIM antibody; Sim2 antibody; SIM2_HUMAN antibody; Single minded homolog 2 (Drosophila) antibody; Single minded homolog 2 antibody; Single-minded homolog 2 antibody; Transcription factor SIM2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SIM2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
  • 基因功能参考文献：
    1. TMEM75 functions as an oncogene relying on activation of SIM2 in colorectal cancer. PMID: 29964097
    2. SIM2 increases CRT sensitivity through tumor differentiation by cooperation with ARNT. PMID: 29427302
    3. Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with prostate cancer. PMID: 28910345
    4. In SH-SY5Y cells, ethanol exposure increased Sim2 expression in a manner similar to that of cleaved caspase 3. PKA activation was required for this. Sim2 might be involved in activating caspase 3 and ethanol-induced apoptosis in SH-SY5Y cells. PMID: 25319570
    5. a single peptide containing multiple SIM2 epitopes can be used to induce both a CD4 and CD8 T cell response, providing a peptide-based vaccine formulation for potential use in immunotherapy of various cancers. PMID: 24690990
    6. Data showed that SIM2 was highly expressed in human glioma tumors and cell lines and its short form might increase the invasion of glioma cells through the alteration of epithelial-mesenchymal transition. PMID: 24909296
    7. miR-200a is downregulated in human glioma and inhibition of miR-200a caused upregulation of SIM2-s in T98G cells and promoted their motility. PMID: 24162743
    8. role for SIM2s in promoting human breast tumor differentiation and maintaining epithelial integrity. PMID: 22777354
    9. Altered expression of SIM2 and ETS2 could be one of the reasons for variable occurrence of different malignant conditions in Down syndrome. PMID: 23343470
    10. These results suggest an involvement of SIM2 in key traits of prostate tumor cell biology. PMID: 22174909
    11. Significantly lower frequency of SIM2 C-G haplotype (rs2073601-rs2073416) was noticed in individuals with Down syndrome (P value =0.01669) and their fathers (P value=0.01185) PMID: 22048266
    12. Genetic variants of SIM2 gene may not be associated with the susceptibility to congenital scoliosis and different clinical phenotypes of CS in Chinese Han population. PMID: 20137643
    13. The SIM2 is expressed in prostate cancer(PCa) and that anti-SIM2 antibodies are detectable in PCa patients' sera implicate SIM2 as a PCa-associated antigen that is a suitable potential target for PCa immunotherapy. PMID: 19737960
    14. Isoform-specific expression of SIM2 short-form (SIM2-s) was seen selectively in colon, prostate, and pancreatic carcinomas. PMID: 12676991
    15. a novel NXF signaling system on neural gene promoter may be a molecular target of the adverse effects of Sim2 in the mental retardation of Down's syndrome PMID: 14701734
    16. Potential role of SIM2 in central nervous system development. SIM2 overexpression could participate in pathogenesis of mental retardation in Down syndrome. PMID: 15946822
    17. provide a direct link between SIM2-s and differentiation, and may provide a model to identify SIM2-s targets PMID: 16129820
    18. Knockdown of SIM2s in MCF-7 breast cancer cells contributed to an epithelial-mesenchymal transition associated with increased MMP2 and slug levels. PMID: 18160708
    19. Ha-Ras transformation of MCF10A cells leads to repression of Singleminded-2s through NOTCH and C/EBPbeta. PMID: 19169276
    20. SIM2s' functional interference with HIF1alpha activities on BNIP3 may indicate a novel role for SIM2s in promoting tumourigenesis. PMID: 19668230
    21. The expression of a splice variant of SIM2, SIM2s, is lost or reduced in human breast cancers. Inhibits growth and invasiveness of breast cancer cells upon ectopic expression. Represses MMP3 expression by direct binding to the MMP3 promoter. PMID: 16840439
    22. Tissue- and tumor-specific expression of both SIM2 isoforms (SIM2-s and SIM2-l), but not SIM1, were detected in the pancreatic tumor models. PMID: 14550949
    23. Stage-specific expression of the sim2-short-form protein was seen in normal matched paraffin sections of the colon tumors. In a matched set of tissues of Benign Prostatic Hyperplasia (BPH) and prostate carcinomas, sim2-s expression was detected in the BPH PMID: 12530058

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 10883

    OMIM: 600892

    KEGG: hsa:6493

    STRING: 9606.ENSP00000290399

    UniGene: Hs.146186