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SLC22A3 Antibody

  • 货号：
    CSB-PA003508
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT29 cells using OCT3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O75751
  • 基因名：
    SLC22A3
  • 别名：
    SLC22A3; EMTH; OCT3; Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human 40819.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.
  • 基因功能参考文献：
    1. Data show that the common variation in the solute carrier family 22 member 3 (SLC22A3) gene is unlikely to significantly contribute to pancreatic cancer risk, and the rs2504938 single nucleotide polymorphism (SNP) in SLC22A3 significantly associates with an unfavorable prognosis of pancreatic cancer patients. PMID: 28272475
    2. SNPs in SLC22A3 and H3F3B may influence lipid levels through altering the expression of local genes. PMID: 29894858
    3. A-to-I RNA editing of SLC22A3 contributes to the early development and progression of familial esophageal squamous cell carcinoma in high-risk individuals. PMID: 28533408
    4. our study suggests that several PHACTR1 and SLC22A3 gene polymorphisms may exert a protective effect against the CAD in the Chinese Han male population. PMID: 27893421
    5. SLC22A3 deletion is associated with motor speech disorders, and language delays. PMID: 28767196
    6. may be a regulator of the concentration of norepinephrine in adipose tissue. PMID: 28034777
    7. the rs3088442G>A variant as a genetic marker may potentially assist in the identification of individuals at an increased risk of T2D. PMID: 28625319
    8. The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population. PMID: 27417586
    9. Findings suggest that OCT3 plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action. PMID: 25920679
    10. The markers of EMT were detected by using Western blot. PMID: 25322669
    11. Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD). PMID: 25561729
    12. Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3. PMID: 24471494
    13. There was no association between rs7758229 in 6q26-q27/SLC22A3 and the risk of colorectal cancer in a Chinese population. PMID: 23555006
    14. Decreasing expression of OCT3 and MATE1 in human placenta indicates these transporters may play a role in fetal protection preferentially at earlier stages of gestation. PMID: 23303678
    15. Our studies demonstrate that genetic polymorphisms in the proximal promoter region of OCT3 alter the transcription rate of the gene and may be associated with altered expression levels of OCT3 in human liver. PMID: 22231567
    16. The increased Wnt3 in the trastuzumab-resistant cells also promoted a partial EMT-like transition. PMID: 23071104
    17. PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
    18. The risk for coronary artery disease in a Chinese Han population is not associated with single nucleotide polymorphisms in the SLC22A3-LPAL2-LPA gene cluster. PMID: 23036009
    19. NUDT11, HNF1B, and SLC22A3 genes have roles in prostate cancer pathogenesis PMID: 22730461
    20. SLC22A3 was expressed high in the human heart with strongest OCT3 immunoreactivity in vascular endothelial cells. SLC22A3/OCT3 expression was not changed in failing human left ventricular myocardium PMID: 21697722
    21. OCT3 overexpression significantly increased cisplatin cellular accumulation and cytotoxicity in KB-3-1 cells. PMID: 21905038
    22. evidence for a new means of downregulating IL-4 production by basophils, both in vitro and in vivo, through OCT3 targeted by 5-HT and pharmacologic ligands. PMID: 21636115
    23. Genetic association studies indicate 5 SNPs are associated with reduced transport activity of OCT3 (using 5-HT & MPP). PMID: 20562519
    24. The regulation of EMT-mediated transport by second-messenger phosphorylation/dephosphorylation mechanisms has been characterized in stably transfected HEK293 cells with tritiated 1-methyl-4-phenylpyridinium as substrate. PMID: 11770002
    25. EMT efficiently translocates agmatine and must be considered for the control of agmatine levels. PMID: 12538837
    26. Genetic variation of EMT was studied in Caucasians. PMID: 12768439
    27. EMT is expressed in the area postrema of rat brain and may play a role in physiological functions of this circumventricular organ such as emesis, food intake and the regulation of cardiovascular functions. PMID: 14690517
    28. organic cation transporter EMT mRNA was mainly detected in the intra lobular septa and also expressed in scattered cells of placental vessel adventitias with lower expression of EMT mRNAs in pre-eclamptic placentae PMID: 15135235
    29. Ranitidine and famotidine elicited differential inhibitory activities on SLC22A3. PMID: 16141367
    30. These results suggest that polymorphisms of SLC22A3 are related to the development of polysubstance use in Japanese patients with methamphetamine (MAP) dependence. PMID: 17010131
    31. PMAT, EMT, and OCT2 transporters are expressed in the endometrial stroma and can potentially regulate reuptake of monoamines in general and histamine in particular. PMID: 17393420
    32. rare mutations in the EMT gene suggest a causative or modulating role in genetic subtypes of obsessive-compulsive disorder PMID: 17477885
    33. Confirm the usefulness of Caki-1 cells as a proximal tubule model system for investigations of OCT3. PMID: 18253050
    34. We conclude that the proliferation of immature germ cells in GB may be due to an interaction between OCT3/4 and accumulated beta-catenin in the nuclei of the immature germ cells. PMID: 18295396
    35. Identification of the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease. PMID: 19198611

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family
  • 组织特异性：
    Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen.
  • 数据库链接：

    HGNC: 10967

    OMIM: 604842

    KEGG: hsa:6581

    STRING: 9606.ENSP00000275300

    UniGene: Hs.567337