Recombinant Human Solute carrier family 22 member 3 (SLC22A3)

1. Data show that the common variation in the solute carrier family 22 member 3 (SLC22A3) gene is unlikely to significantly contribute to pancreatic cancer risk, and the rs2504938 single nucleotide polymorphism (SNP) in SLC22A3 significantly associates with an unfavorable prognosis of pancreatic cancer patients. PMID: 28272475
2. SNPs in SLC22A3 and H3F3B may influence lipid levels through altering the expression of local genes. PMID: 29894858
3. A-to-I RNA editing of SLC22A3 contributes to the early development and progression of familial esophageal squamous cell carcinoma in high-risk individuals. PMID: 28533408
4. our study suggests that several PHACTR1 and SLC22A3 gene polymorphisms may exert a protective effect against the CAD in the Chinese Han male population. PMID: 27893421
5. SLC22A3 deletion is associated with motor speech disorders, and language delays. PMID: 28767196
6. may be a regulator of the concentration of norepinephrine in adipose tissue. PMID: 28034777
7. the rs3088442G>A variant as a genetic marker may potentially assist in the identification of individuals at an increased risk of T2D. PMID: 28625319
8. The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population. PMID: 27417586
9. Findings suggest that OCT3 plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action. PMID: 25920679
10. The markers of EMT were detected by using Western blot. PMID: 25322669
11. Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD). PMID: 25561729
12. Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3. PMID: 24471494
13. There was no association between rs7758229 in 6q26-q27/SLC22A3 and the risk of colorectal cancer in a Chinese population. PMID: 23555006
14. Decreasing expression of OCT3 and MATE1 in human placenta indicates these transporters may play a role in fetal protection preferentially at earlier stages of gestation. PMID: 23303678
15. Our studies demonstrate that genetic polymorphisms in the proximal promoter region of OCT3 alter the transcription rate of the gene and may be associated with altered expression levels of OCT3 in human liver. PMID: 22231567
16. The increased Wnt3 in the trastuzumab-resistant cells also promoted a partial EMT-like transition. PMID: 23071104
17. PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
18. The risk for coronary artery disease in a Chinese Han population is not associated with single nucleotide polymorphisms in the SLC22A3-LPAL2-LPA gene cluster. PMID: 23036009
19. NUDT11, HNF1B, and SLC22A3 genes have roles in prostate cancer pathogenesis PMID: 22730461
20. SLC22A3 was expressed high in the human heart with strongest OCT3 immunoreactivity in vascular endothelial cells. SLC22A3/OCT3 expression was not changed in failing human left ventricular myocardium PMID: 21697722
21. OCT3 overexpression significantly increased cisplatin cellular accumulation and cytotoxicity in KB-3-1 cells. PMID: 21905038
22. evidence for a new means of downregulating IL-4 production by basophils, both in vitro and in vivo, through OCT3 targeted by 5-HT and pharmacologic ligands. PMID: 21636115
23. Genetic association studies indicate 5 SNPs are associated with reduced transport activity of OCT3 (using 5-HT & MPP). PMID: 20562519
24. The regulation of EMT-mediated transport by second-messenger phosphorylation/dephosphorylation mechanisms has been characterized in stably transfected HEK293 cells with tritiated 1-methyl-4-phenylpyridinium as substrate. PMID: 11770002
25. EMT efficiently translocates agmatine and must be considered for the control of agmatine levels. PMID: 12538837
26. Genetic variation of EMT was studied in Caucasians. PMID: 12768439
27. EMT is expressed in the area postrema of rat brain and may play a role in physiological functions of this circumventricular organ such as emesis, food intake and the regulation of cardiovascular functions. PMID: 14690517
28. organic cation transporter EMT mRNA was mainly detected in the intra lobular septa and also expressed in scattered cells of placental vessel adventitias with lower expression of EMT mRNAs in pre-eclamptic placentae PMID: 15135235
29. Ranitidine and famotidine elicited differential inhibitory activities on SLC22A3. PMID: 16141367
30. These results suggest that polymorphisms of SLC22A3 are related to the development of polysubstance use in Japanese patients with methamphetamine (MAP) dependence. PMID: 17010131
31. PMAT, EMT, and OCT2 transporters are expressed in the endometrial stroma and can potentially regulate reuptake of monoamines in general and histamine in particular. PMID: 17393420
32. rare mutations in the EMT gene suggest a causative or modulating role in genetic subtypes of obsessive-compulsive disorder PMID: 17477885
33. Confirm the usefulness of Caki-1 cells as a proximal tubule model system for investigations of OCT3. PMID: 18253050
34. We conclude that the proliferation of immature germ cells in GB may be due to an interaction between OCT3/4 and accumulated beta-catenin in the nuclei of the immature germ cells. PMID: 18295396
35. Identification of the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease. PMID: 19198611

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HGNC: 10967

OMIM: 604842

KEGG: hsa:6581

STRING: 9606.ENSP00000275300

UniGene: Hs.567337